Description

tert-Butyl (4-Ethynylpyridin-2-Yl)Carbamate CAS NO 1196145-93-3 is a high-purity, advanced pharmaceutical intermediate featuring a pyridine core with both carbamate and ethynyl functional groups. This compound is valued for its role as a versatile building block in medicinal chemistry, enabling the synthesis of complex molecules through cross-coupling and click chemistry reactions. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs) and drug candidates.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its reactive ethynyl group for further functionalization.
• Bioconjugation & Probe Development: Serves as a precursor for creating chemical probes, biomarkers, and antibody-drug conjugates (ADCs) via copper-catalyzed azide-alkyne cycloaddition (CuAAC).
• Organic Synthesis: Employed in palladium-catalyzed cross-coupling reactions (e.g., Sonogashira, Suzuki) to construct complex heterocyclic systems.
• Chemical Library Production: Utilized in combinatorial chemistry and high-throughput screening to generate diverse compound libraries for biological testing.

Basic Information

Product Name	tert-Butyl (4-Ethynylpyridin-2-Yl)Carbamate
CAS No.	1196145-93-3
Molecular Formula	C12H14N2O2
Molecular Weight	218.25 g/mol
Synonyms	Boc-4-Ethynyl-2-aminopyridine; 2-((tert-Butoxycarbonyl)amino)-4-ethynylpyridine; 4-Ethynyl-2-pyridinamine, N-BOC-protected; tert-Butyl N-(4-ethynyl-2-pyridyl)carbamate; Carbamic acid, N-(4-ethynyl-2-pyridinyl)-, 1,1-dimethylethyl ester; 2-Amino-4-ethynylpyridine, N-Boc derivative; BOC-4-Ethynyl-2-AP
EINECS	Contact for details

Quality Control

Our tert-Butyl (4-Ethynylpyridin-2-Yl)Carbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.