Description

2,5-Dioxopyrrolidin-1-Yl 4-Cyano-4-(((Ethylthio)Carbonothioyl)Thio)Pentanoate is a specialized bifunctional chemical reagent designed for advanced organic synthesis and polymer science. This compound matters because it integrates a reactive N-hydroxysuccinimide (NHS) ester group with a reversible addition-fragmentation chain-transfer (RAFT) agent, enabling precise, controlled polymerizations and bioconjugation strategies. It is essential for researchers and manufacturers in pharmaceuticals, advanced materials, and biotechnology who require high-purity intermediates for creating functional polymers, drug delivery systems, and protein-polymer conjugates.

Application

• RAFT Polymerization: Serves as a functional chain transfer agent (CTA) for the controlled synthesis of polymers with narrow molecular weight distributions and specific end-group functionality.
• Bioconjugation & Protein Labeling: The NHS ester moiety facilitates efficient and stable amide bond formation with primary amines on proteins, antibodies, or peptides for labeling and therapeutic conjugate development.
• Functional Polymer Synthesis: Enables the production of block copolymers, star polymers, and other complex architectures with reactive end-groups for further modification.
• Drug Delivery System Fabrication: Used to synthesize polymer-drug conjugates and stimuli-responsive nanocarriers where controlled release and targeting are critical.
• Surface Modification & Coatings: Applicable for grafting polymers onto surfaces to alter properties like hydrophilicity, biocompatibility, or introducing specific chemical functionalities.
• Advanced Material Research: A key building block in R&D for developing novel hydrogels, self-assembling materials, and smart composites.

Basic Information

Product Name	2,5-Dioxopyrrolidin-1-Yl 4-Cyano-4-(((Ethylthio)Carbonothioyl)Thio)Pentanoate
CAS No.	1195771-65-3
Molecular Formula	C13H16N2O4S3
Molecular Weight	360.47 g/mol
Synonyms	NHS-RAFT Agent; 4-Cyano-4-(((ethylthio)carbonothioyl)thio)pentanoic acid N-hydroxysuccinimide ester; S-Ethyl-S′-(4-cyano-4-(N-succinimidyloxycarbonyl)pentyl)trithiocarbonate; 4-Cyano-4-(trithiocarbonate)pentanoic acid NHS ester; Cyano-RAFT-NHS ester; Functional RAFT chain transfer agent with NHS ester; 2,5-Pyrrolidinedione, 1-[[4-cyano-4-[[(ethylthio)thioxomethyl]thio]-1-oxopentyl]oxy]-
EINECS	Contact for details

Quality Control

Our 2,5-Dioxopyrrolidin-1-Yl 4-Cyano-4-(((Ethylthio)Carbonothioyl)Thio)Pentanoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and FTIR, to ensure high purity and structural integrity suitable for sensitive research and production applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%
Solubility	Soluble in DMF, DMSO, acetonitrile, THF

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.