Description

(S)-7-Hydroxy-1,4-Dioxaspiro[4.5]Decan-8-One is a chiral, high-purity organic intermediate featuring a spirocyclic acetal-protected hydroxy ketone structure. This compound matters as a critical building block for the stereoselective synthesis of complex pharmaceutical molecules and fine chemicals. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced material industries for constructing chiral centers and functionalized cyclic systems.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of active pharmaceutical ingredients (APIs), particularly in routes requiring stereochemical control.
• Asymmetric Synthesis: Used as a precursor or auxiliary in catalytic asymmetric reactions to introduce specific stereochemistry into target molecules.
• Natural Product Synthesis: Serves as a building block in the total synthesis of complex natural products with spirocyclic or polycyclic motifs.
• Agrochemical Research: Employed in the research and development of novel, chiral herbicides, fungicides, and plant growth regulators.
• Material Science: Potential monomer or cross-linking agent for creating specialized polymers with unique thermal or optical properties.
• Chemical Biology Probes: Useful for synthesizing labeled compounds or molecular probes to study biological pathways and enzyme mechanisms.

Basic Information

Product Name	(S)-7-Hydroxy-1,4-Dioxaspiro[4.5]Decan-8-One
CAS No.	1193523-95-3
Molecular Formula	C9H14O4
Molecular Weight	186.21 g/mol
Synonyms	(S)-7-Hydroxy-1,4-dioxaspiro[4.5]decan-8-one; (8S)-8-Hydroxy-1,4-dioxaspiro[4.5]decan-7-one; (S)-8-Hydroxy-1,4-dioxaspiro[4.5]decan-7-one; (S)-7-Hydroxy-1,4-dioxaspiro[4.5]decan-8-one; (S)-1,4-Dioxaspiro[4.5]decan-7-ol-8-one; (S)-7-Hydroxy-8-oxo-1,4-dioxaspiro[4.5]decane; (S)-HODD; (S)-Spirocyclic Hydroxy Ketone Intermediate
EINECS	Contact for details

Quality Control

Our (S)-7-Hydroxy-1,4-Dioxaspiro[4.5]Decan-8-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting R&D and process chemistry standards. Certificates of Analysis (COA) detailing identity, purity, and chiral excess are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after each use to prevent moisture absorption, which may affect stability and reactivity. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.