Description

Methyl 4-Bromo-2-Fluoro-6-Hydroxybenzoate is a high-purity, multi-functional aromatic ester building block designed for advanced organic synthesis. This compound is valued for its precise molecular architecture, featuring strategically placed bromo, fluoro, and hydroxy substituents on a benzoate core, which enables selective chemical transformations. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex target molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring halogenated aromatic motifs.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides where the fluorine and bromine atoms can enhance biological activity and metabolic stability.
• Liquid Crystal & OLED Material Synthesis: Serves as a building block for creating advanced organic electronic materials due to its halogenated, electron-deficient aromatic structure.
• Cross-Coupling Reactions: The bromo substituent makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, and Buchwald-Hartwig aminations.
• Fluorine Chemistry Studies: Employed as a model compound in research exploring the effects of fluorine substitution on aromatic system reactivity and physical properties.
• Polymer Modification: Can be incorporated as a functional monomer or used to modify polymer side chains to impart specific chemical or physical characteristics.

Basic Information

Product Name	Methyl 4-Bromo-2-Fluoro-6-Hydroxybenzoate
CAS No.	1193162-18-3
Molecular Formula	C8H6BrFO3
Molecular Weight	249.04 g/mol
Synonyms	Methyl 4-bromo-2-fluoro-6-hydroxybenzoate; 4-Bromo-2-fluoro-6-hydroxybenzoic acid methyl ester; Benzoic acid, 4-bromo-2-fluoro-6-hydroxy-, methyl ester; 2-Fluoro-6-hydroxy-4-bromobenzoic acid methyl ester; Methyl 2-fluoro-6-hydroxy-4-bromobenzoate
EINECS	Contact for details

Quality Control

Our production of Methyl 4-Bromo-2-Fluoro-6-Hydroxybenzoate adheres to stringent internal quality standards to ensure batch-to-batch consistency and reliability for sensitive synthetic applications. Each lot is characterized using advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be light-sensitive and should be handled under an inert atmosphere for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.