Description

1-Piperidinecarboxylic Acid, 4-Hydroxy-4-(2-Methylpropyl)-, 1,1-Dimethylethyl Ester is a high-purity, protected amino acid derivative of significant interest in advanced organic synthesis. This compound serves as a critical chiral building block and intermediate for the development of novel active pharmaceutical ingredients (APIs) and fine chemicals. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop new therapeutic agents and complex molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, particularly for central nervous system (CNS) and metabolic disorder targets.
• Peptidomimetic Synthesis: Used to introduce constrained, functionalized piperidine motifs into peptide backbones to enhance stability and biological activity.
• Agrochemical Research: Serves as a building block for novel herbicides, fungicides, and plant growth regulators requiring specific stereochemistry.
• Ligand and Catalyst Development: Employed in the synthesis of chiral ligands and organocatalysts for asymmetric synthesis applications.
• Custom Chemical Synthesis: Provides a versatile starting material for contract research organizations (CROs) and CDMOs producing bespoke fine chemicals.
• Academic & Industrial R&D: A valuable reagent for methodological studies in organic chemistry and medicinal chemistry programs.

Basic Information

Product Name	1-Piperidinecarboxylic Acid, 4-Hydroxy-4-(2-Methylpropyl)-, 1,1-Dimethylethyl Ester
CAS No.	1192122-38-5
Molecular Formula	C14H27NO3
Molecular Weight	257.37 g/mol
Synonyms	tert-Butyl 4-hydroxy-4-isobutylpiperidine-1-carboxylate; 4-Hydroxy-4-isobutylpiperidine-1-carboxylic acid tert-butyl ester; Boc-4-hydroxy-4-isobutylpiperidine; N-Boc-4-hydroxy-4-isobutylpiperidine; 1-(tert-Butoxycarbonyl)-4-hydroxy-4-isobutylpiperidine; 4-Isobutyl-4-hydroxypiperidine-1-carboxylic acid tert-butyl ester; 4-(2-Methylpropyl)-4-hydroxypiperidine-1-carboxylic acid 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our production of 1-Piperidinecarboxylic Acid, 4-Hydroxy-4-(2-Methylpropyl)-, 1,1-Dimethylethyl Ester adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. The material is characterized and released according to comprehensive in-house specifications, which are aligned with ICH guidelines for pharmaceutical intermediates. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 99.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.