Description

Methyl 2-Amino-3-(Tetrahydro-2H-Pyran-4-Yl)Propanoate is a high-purity, protected amino acid ester derivative that serves as a critical chiral building block in advanced organic synthesis. Its value lies in providing a versatile scaffold for constructing complex molecules with precise stereochemistry, essential for developing bioactive compounds. This intermediate is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers focused on producing novel active pharmaceutical ingredients (APIs), peptide mimetics, and other high-value specialty chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and metabolic disorder research.
• Peptidomimetic Chemistry: Used to incorporate constrained, non-natural amino acid residues into peptide backbones to enhance stability and bioavailability.
• Asymmetric Synthesis: Serves as a starting material or intermediate in catalytic asymmetric transformations to create enantiomerically pure compounds.
• Medicinal Chemistry & SAR Studies: Employed to explore structure-activity relationships by introducing the tetrahydro-2H-pyran moiety into lead compounds.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke molecules at various scales.
• Agrochemical Research: Potential intermediate in the development of new chiral active ingredients for crop protection.

Basic Information

Product Name	Methyl 2-Amino-3-(Tetrahydro-2H-Pyran-4-Yl)Propanoate
CAS No.	1192057-13-8
Molecular Formula	C9H17NO3
Molecular Weight	187.24 g/mol
Synonyms	Methyl 2-amino-3-(tetrahydro-2H-pyran-4-yl)propanoate; 2-Amino-3-(tetrahydro-2H-pyran-4-yl)propanoic acid methyl ester; L-2-Amino-3-(tetrahydro-2H-pyran-4-yl)propionic acid methyl ester; Methyl (S)-2-amino-3-(tetrahydro-2H-pyran-4-yl)propanoate; Methyl 2-amino-3-(oxan-4-yl)propanoate; 1192057-13-8; THP-protected amino acid ester; 4-(2-Methoxy-2-oxo-1-((S)-2-aminoethyl)ethyl)tetrahydro-2H-pyran
EINECS	Contact for details

Quality Control

Our Methyl 2-Amino-3-(Tetrahydro-2H-Pyran-4-Yl)Propanoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider using desiccant in the storage environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.