Description

Tco-Carbonate CAS NO 1191901-33-3 is a specialized carbonate-protected amino acid derivative, primarily used as a key synthetic intermediate in advanced organic chemistry. Its core value lies in providing a robust, orthogonal protecting group strategy for amines, enabling complex multi-step synthesis in sensitive applications. This compound is essential for researchers and manufacturers in pharmaceutical development, particularly in the synthesis of peptides, oligonucleotides, and other bioactive molecules where precise control over reaction sequences is critical.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of active pharmaceutical ingredients (APIs) and novel drug candidates.
• Peptide Synthesis: Used for the temporary protection of amino groups during solid-phase and solution-phase peptide synthesis.
• Oligonucleotide & PROTAC Development: Serves as a key reagent in the production of complex biomolecules and targeted protein degraders.
• Chemical Biology & Bioconjugation: Enables the site-specific modification of proteins and other biomolecules for research and diagnostic applications.
• Academic & Industrial R&D: Employed in research laboratories for method development and the exploration of new synthetic pathways.
• Scale-up Process Chemistry: Suitable for process optimization and pilot-scale manufacturing of advanced intermediates.

Basic Information

Product Name	Tco-Carbonate
CAS No.	1191901-33-3
Molecular Formula	C₁₀H₁₅NO₅
Molecular Weight	229.23 g/mol
Synonyms	trans-Cyclooctene Carbonate; TCO-PNB Carbonate; (E)-Cyclooct-4-enyl (4-nitrophenyl) carbonate; 4-Nitrophenyl (E)-cyclooct-4-en-1-yl carbonate; TCO-PNP Carbonate; TCO activated carbonate; TCO-NPC; TCO Carbonate Ester
EINECS	Contact for details

Quality Control

Our Tco-Carbonate is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing to ensure high purity and consistency, meeting the stringent requirements for research and cGMP-grade pharmaceutical intermediates. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and impurity profiles as determined by HPLC, NMR, and mass spectrometry.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture uptake. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Individual impurity ≤ 1.0%
Total Impurities	≤ 5.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.