Description

3,3-Dimethyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)indolin-2-one is a high-purity, synthetically valuable boronic ester derivative of the oxindole scaffold. This compound matters as a critical pharmaceutical intermediate and Suzuki-Miyaura cross-coupling building block, enabling the efficient construction of complex molecules for drug discovery. It is primarily needed by R&D chemists and process development teams in the pharmaceutical, agrochemical, and advanced materials sectors seeking to introduce functionalized indolinone motifs into target structures.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly kinase inhibitors and other small molecule therapeutics.
• Suzuki-Miyaura Cross-Coupling Reactions: Enables the formation of carbon-carbon bonds to attach complex aryl and heteroaryl groups to the indolinone core.
• Agrochemical Research: Used in the development of new active ingredients with potential herbicidal or insecticidal properties.
• Material Science: Serves as a precursor for organic electronic materials and functional polymers.
• Chemical Biology & Proteolysis Targeting Chimeras (PROTACs): Utilized in the construction of bifunctional molecules for targeted protein degradation.
• Library Synthesis for High-Throughput Screening: Provides a versatile handle for generating diverse compound libraries.

Basic Information

Product Name	3,3-Dimethyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)indolin-2-one
CAS No.	1190861-74-5
Molecular Formula	C16H22BNO3
Molecular Weight	287.16 g/mol
Synonyms	6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3,3-dimethylindolin-2-one; 3,3-Dimethyl-2-oxoindoline-6-boronic acid pinacol ester; 6-Borono-3,3-dimethylindolin-2-one pinacol ester; 3,3-Dimethyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,3-dihydro-2H-indol-2-one; 6-(Pinacolatoboryl)-3,3-dimethylindolin-2-one; 3,3-Dimethyl-6-(pinacolboron)oxindole
EINECS	Contact for details

Quality Control

Our 3,3-Dimethyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)indolin-2-one is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for pharmaceutical R&D and process chemistry. Certificates of Analysis (COA) with detailed specifications are available for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and potential degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.