Description

6'-Bromospiro[Cyclobutane-1,3'-Indolin]-2'-One is a high-value, spirocyclic organic building block featuring a brominated indolinone scaffold fused to a cyclobutane ring. This unique molecular architecture makes it a critical intermediate for medicinal chemistry research and the synthesis of complex bioactive molecules. It is primarily sought after by pharmaceutical R&D teams and fine chemical manufacturers engaged in developing novel therapeutic agents, particularly for targeted protein degradation and kinase inhibitor programs.

Application

• Pharmaceutical Intermediate: A key synthon for the construction of spirocyclic drug candidates in oncology, neurology, and anti-inflammatory research.
• PROTAC & Molecular Glue Development: Serves as a versatile linker or warhead component in the design of proteolysis-targeting chimeras (PROTACs) and other bifunctional molecules.
• Kinase Inhibitor Synthesis: Used in the preparation of selective kinase inhibitors due to its ability to modulate binding affinity and selectivity profiles.
• Chemical Biology Probes: Employed in the synthesis of tool compounds for studying enzyme function and cellular signaling pathways.
• Agrochemical Research: Acts as a precursor for novel active ingredients with potential herbicidal or insecticidal properties.
• Material Science: Investigated as a monomer or precursor for advanced organic electronic materials and polymers.

Basic Information

Product Name	6'-Bromospiro[Cyclobutane-1,3'-Indolin]-2'-One
CAS No.	1190861-39-2
Molecular Formula	C11H10BrNO
Molecular Weight	252.11 g/mol
Synonyms	6'-Bromo-1'H-spiro[cyclobutane-1,3'-indol]-2'(2'H)-one; 6'-Bromospiro[cyclobutane-1,3'-indolin]-2'-one; 2H-Indol-2-one, 1,3-dihydro-6'-bromospiro[cyclobutane-1,3'-[3H]indol]-2'-one; 6-Bromospiro[cyclobutane-1,3'-indolin]-2'-one; Spiro[cyclobutane-1,3'-indolin]-2'-one, 6'-bromo-; 1190861-39-2
EINECS	Contact for details

Quality Control

Our 6'-Bromospiro[Cyclobutane-1,3'-Indolin]-2'-One is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical characterization, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be light-sensitive; prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.