Description

(R)-9-((Triisopropylsilyl)Oxy)-6,7,8,9-Tetrahydro-5H-Cyclohepta[B]Pyridin-5-Onehydrochloride is a high-purity, chiral synthetic intermediate of significant importance in modern pharmaceutical research and development. This compound is specifically designed for the synthesis of complex, biologically active molecules, offering a key stereochemical handle for constructing advanced therapeutic agents. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries for the production of novel drug candidates, particularly in areas requiring precise stereocontrol.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), especially for central nervous system (CNS) and anti-infective drug candidates.
• Chiral Synthesis: Utilized in asymmetric synthesis to introduce the (R)-configuration into complex molecular scaffolds, ensuring the desired biological activity of the final drug product.
• Process Chemistry & Scale-Up: Serves as a key starting material for process research, route scouting, and the development of scalable, cost-effective manufacturing processes for new chemical entities.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical space and improve drug-like properties.
• Reference Standard: Can be supplied as a high-purity analytical standard for method development, quality control, and regulatory submissions.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) engaged in the custom synthesis of complex molecules for clinical trials.

Basic Information

Product Name	(R)-9-((Triisopropylsilyl)Oxy)-6,7,8,9-Tetrahydro-5H-Cyclohepta[B]Pyridin-5-Onehydrochloride
CAS No.	1190363-45-1
Molecular Formula	C22H36ClNO2Si
Molecular Weight	410.07 g/mol
Synonyms	(R)-9-OTIPS-6,7,8,9-Tetrahydro-5H-Cyclohepta[b]pyridin-5-one Hydrochloride; (R)-9-(Triisopropylsilyloxy)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-5-one hydrochloride; 5H-Cyclohepta[b]pyridin-5-one, 6,7,8,9-tetrahydro-9-[(triisopropylsilyl)oxy]-, hydrochloride, (9R)-; (R)-TIPS-protected Cycloheptapyridone Hydrochloride; CAS 1190363-45-1
EINECS	Contact for details

Quality Control

Our (R)-9-((Triisopropylsilyl)Oxy)-6,7,8,9-Tetrahydro-5H-Cyclohepta[B]Pyridin-5-Onehydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting pharmaceutical-grade standards. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening the primary container to prevent degradation. Keep away from fluoride sources and strong alkali.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.