Description

Methyl 5-(Difluoromethoxy)-2-methylbenzoate is a high-purity organic ester compound featuring a difluoromethoxy substituent, a key structural motif in advanced chemical synthesis. This compound serves as a critical pharmaceutical intermediate and building block for the development of novel active ingredients. It is primarily utilized by R&D and production teams in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate fluorinated moieties into target molecules.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring a difluoromethoxybenzene core for enhanced metabolic stability and bioavailability.
• Agrochemical Research: Used as a building block in the development of new-generation herbicides, fungicides, and insecticides where fluorine atoms improve efficacy and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated organic compounds for electronic applications, including liquid crystal displays and organic light-emitting diodes.
• Organic Synthesis & Catalysis: Employed in cross-coupling reactions and other catalytic processes to construct complex, fluorinated aromatic structures for material science.
• Fluorine Chemistry Research: A valuable reference standard and starting material in academic and industrial labs focused on exploring new fluorination methodologies and reaction pathways.

Basic Information

Product Name	Methyl 5-(Difluoromethoxy)-2-methylbenzoate
CAS No.	1190320-23-0
Molecular Formula	C10H10F2O3
Molecular Weight	216.18 g/mol
Synonyms	5-(Difluoromethoxy)-2-methylbenzoic acid methyl ester; Methyl 5-(difluoromethoxy)-o-toluate; Benzoic acid, 5-(difluoromethoxy)-2-methyl-, methyl ester; 2-Methyl-5-(difluoromethoxy)benzoic acid methyl ester; Methyl 2-methyl-5-(difluoromethoxy)benzoate
EINECS	Contact for details

Quality Control

Our production of Methyl 5-(Difluoromethoxy)-2-methylbenzoate adheres to stringent internal quality standards to ensure batch-to-batch consistency and high purity. Each lot is characterized and released with a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We support cGMP compliance for pharmaceutical applications and can provide material for regulatory filings upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Keep away from strong alkalis and incompatible organic solvents. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.