Description

2H-Pyrrolo[2,3-B]Pyridin-2-One,5-Bromo-1,3-Dihydro-6-Methoxy- is a high-purity, advanced pharmaceutical intermediate of significant commercial and research interest. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of novel, complex molecules. It is primarily needed by pharmaceutical R&D departments and fine chemical manufacturers focused on developing new active pharmaceutical ingredients (APIs), particularly in oncology and central nervous system (CNS) therapeutic areas.

Application

• Pharmaceutical Intermediate: Serves as a key synthetic precursor in the development of novel drug candidates, especially kinase inhibitors and other targeted therapies.
• Medicinal Chemistry Research: Used extensively in structure-activity relationship (SAR) studies and lead optimization processes within drug discovery pipelines.
• Organic Synthesis Building Block: The bromo and methoxy functional groups make it a versatile reagent for further functionalization via cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig).
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and target validation.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and scale-up of complex organic molecules for clinical trials.

Basic Information

Product Name	2H-Pyrrolo[2,3-B]Pyridin-2-One,5-Bromo-1,3-Dihydro-6-Methoxy-
CAS No.	1190316-90-5
Molecular Formula	C8H7BrN2O2
Molecular Weight	243.06 g/mol
Synonyms	5-Bromo-6-methoxy-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one; 5-Bromo-6-methoxy-2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-2-one; 1,3-Dihydro-5-bromo-6-methoxy-2H-pyrrolo[2,3-b]pyridin-2-one; 5-Bromo-6-methoxy-1H-pyrrolo[2,3-b]pyridin-2(3H)-one; 5-Bromo-6-methoxy-2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-2-one; 5-Bromo-6-methoxy-2-oxo-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine
EINECS	Contact for details

Quality Control

Our 2H-Pyrrolo[2,3-B]Pyridin-2-One,5-Bromo-1,3-Dihydro-6-Methoxy- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, ensuring full traceability and compliance with your internal quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is light-sensitive (store away from light). For long-term storage, consider storage under inert atmosphere to ensure optimal stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.