Description

Diethyl 2-Aceto-3-(4-Chlorophenyl-D4)Glutarate is a high-purity, deuterium-labeled organic compound primarily used as a critical intermediate in pharmaceutical research and development. This deuterated analog is essential for creating internal standards in mass spectrometry, enabling precise quantitative analysis and metabolic studies. It is specifically valuable for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced material sectors who require isotopically labeled building blocks for drug discovery, pharmacokinetics, and environmental fate studies.

Application

• Pharmaceutical Intermediate: A key deuterated synthon in the synthesis of novel active pharmaceutical ingredients (APIs) and their metabolites.
• Analytical Reference Standard: Serves as an internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS) and Gas Chromatography-Mass Spectrometry (GC-MS) for accurate quantification in complex matrices.
• Metabolic Pathway Tracing: Utilized in drug metabolism and pharmacokinetics (DMPK) studies to track the absorption, distribution, metabolism, and excretion (ADME) of parent compounds.
• Isotope Labeling: Employed in the preparation of deuterium-labeled compounds for use in mechanistic studies and to potentially improve the metabolic stability of candidate drugs.
• Agrochemical Research: Used in the development and analysis of new pesticides and herbicides where isotopic labeling is required for environmental and residue studies.
• Academic & Contract Research: A valuable tool for universities and CROs (Contract Research Organizations) conducting advanced organic synthesis and analytical method development.

Basic Information

Product Name	Diethyl 2-Aceto-3-(4-Chlorophenyl-D4)Glutarate
CAS No.	1189724-35-3
Molecular Formula	C17H17D4ClO5
Molecular Weight	352.82 g/mol (approx.)
Synonyms	Diethyl 2-acetyl-3-(4-chlorophenyl-2,3,5,6-d4)glutarate; 2-Acetyl-3-(4-chlorophenyl-d4)pentanedioic Acid Diethyl Ester; 3-(4-Chlorophenyl-d4)-2-acetylglutaric Acid Diethyl Ester; Deuterated Diethyl 2-Aceto-3-(4-Chlorophenyl)Glutarate; Diethyl (4-Chlorophenyl-d4)acetylglutarate; Glutaric acid, 2-acetyl-3-(4-chlorophenyl-d4)-, diethyl ester
EINECS	Contact for details

Quality Control

Our Diethyl 2-Aceto-3-(4-Chlorophenyl-D4)Glutarate is manufactured under strict quality control protocols to ensure high chemical purity and isotopic enrichment. Each batch is characterized by advanced analytical techniques including NMR, HPLC, and Mass Spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, deuterium incorporation, and impurity profile is provided with every shipment to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic (moisture-sensitive); therefore, containers should be kept tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Deuterium Incorporation	≥ 98 atom % D
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.