Description

(trans-Racemic)-Methyl 1-Benzyl-4-(2-((tert-Butyldimethylsilyloxy)Methyl)Furo[3,2-B]Pyridin-6-Yl)Pyr is a high-purity, advanced pharmaceutical intermediate featuring a complex heterocyclic structure. This compound is of significant value for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated molecular architectures. It is primarily needed by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in drug discovery and process development.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of potential drug candidates, especially those targeting central nervous system (CNS) disorders or oncology.
• Drug Discovery Research: Used in medicinal chemistry programs for structure-activity relationship (SAR) studies and lead optimization due to its fused furopyridine core.
• Process Chemistry Development: Employed in scaling up synthetic routes from laboratory to pilot plant scale, requiring consistent high purity and reliable supply.
• Reference Standard: Can be supplied as a characterized standard for analytical method development, validation, and quality control in API manufacturing.
• Academic Research: Utilized in university and institutional labs for studying heterocyclic chemistry, asymmetric synthesis, and new catalytic methodologies.

Basic Information

Product Name	(trans-Racemic)-Methyl 1-Benzyl-4-(2-((tert-Butyldimethylsilyloxy)Methyl)Furo[3,2-B]Pyridin-6-Yl)Pyr
CAS No.	1189172-05-1
Molecular Formula	C27H34N2O3Si
Molecular Weight	462.67 g/mol
Synonyms	Methyl 1-benzyl-4-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]furo[3,2-b]pyridin-6-yl]-1H-pyrrole-2-carboxylate (trans-racemic); 1-Benzyl-4-(2-(((tert-butyldimethylsilyl)oxy)methyl)furo[3,2-b]pyridin-6-yl)-1H-pyrrole-2-carboxylic acid methyl ester (racemic trans); TBS-protected furo[3,2-b]pyridine pyrrole intermediate; trans-1-Benzyl-4-(2-((TBDMS-oxymethyl))furo[3,2-b]pyridin-6-yl)pyrrole-2-carboxylate; 1189172-05-1; tert-Butyldimethyl((6-(1-benzyl-2-(methoxycarbonyl)-1H-pyrrol-4-yl)furo[3,2-b]pyridin-2-yl)methoxy)silane
EINECS	Contact for details

Quality Control

Our (trans-Racemic)-Methyl 1-Benzyl-4-(2-((tert-Butyldimethylsilyloxy)Methyl)Furo[3,2-B]Pyridin-6-Yl)Pyr is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical characterization, including HPLC for purity, NMR and MS for structural confirmation, and chiral analysis to confirm the racemic trans nature. Certificates of Analysis (COA) detailing all test results are provided and can be tailored to meet specific client or regulatory requirements for research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive (store away from light). For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen to ensure optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
trans-Isomer Content (HPLC)	≥ 98.0% of total isomers
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.