Description

(E)-Methyl 3-(2-((tert-Butyldimethylsilyloxy)-Methyl)Furo[3,2-B]Pyridin-6-Yl)Acrylate is a high-purity, advanced pharmaceutical intermediate featuring a unique furo[3,2-b]pyridine core with a protected hydroxymethyl group and an acrylate ester moiety. This compound is specifically designed for use in complex multi-step synthesis, offering a critical building block for medicinal chemistry research and development. It is essential for researchers and process chemists in the pharmaceutical and biotechnology industries working on novel active pharmaceutical ingredients (APIs), particularly in oncology and antiviral therapeutic areas.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of novel drug candidates, particularly those targeting kinase inhibition.
• Medicinal Chemistry Research: Used as a versatile building block for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• API Synthesis: Serves as a critical component in the multi-step synthesis of complex Active Pharmaceutical Ingredients (APIs) for preclinical and clinical trials.
• Chemical Biology Probes: Utilized in the development of molecular probes for studying biological pathways and target validation.
• Process Development: Employed in scaling up synthetic routes from laboratory to pilot plant scale for new therapeutic agents.
• Custom Synthesis: Acts as a starting material for the custom synthesis of more complex, proprietary compounds under contract research and manufacturing (CRAM) agreements.

Basic Information

Item	Detail
Product Name	(E)-Methyl 3-(2-((tert-Butyldimethylsilyloxy)-Methyl)Furo[3,2-B]Pyridin-6-Yl)Acrylate
CAS No.	1189171-55-8
Molecular Formula	C19H25NO4Si
Molecular Weight	359.50 g/mol
Synonyms	Methyl (2E)-3-[2-[[(1,1-Dimethylethyl)dimethylsilyl]oxymethyl]furo[3,2-b]pyridin-6-yl]-2-propenoate; (E)-Methyl 3-(2-((tert-butyldimethylsilyloxy)methyl)furo[3,2-b]pyridin-6-yl)acrylate; TBS-protected Furopyridine Acrylate; Methyl (E)-3-(2-(((tert-butyldimethylsilyl)oxy)methyl)furo[3,2-b]pyridin-6-yl)acrylate; 6-Acrylate Furo[3,2-b]pyridine TBS Ether
EINECS	Contact for details

Quality Control

Our (E)-Methyl 3-(2-((tert-Butyldimethylsilyloxy)-Methyl)Furo[3,2-B]Pyridin-6-Yl)Acrylate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development applications. All products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with each shipment to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere such as nitrogen or argon to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.