Description

Methyl 3,3,3-Trifluoro-2,2-Dimethylpropanoate is a high-value fluorinated ester building block, distinguished by its unique gem-dimethyl and trifluoromethyl groups. This structure offers exceptional metabolic stability and lipophilicity, making it a critical intermediate for advanced material and pharmaceutical synthesis. It is primarily sought by R&D chemists and process development scientists in the agrochemical, pharmaceutical, and specialty polymer industries for constructing complex, performance-enhancing molecules.

Application

• Pharmaceutical Intermediate: Key synthon for introducing the trifluoromethyl group into active pharmaceutical ingredients (APIs) to improve bioavailability and metabolic resistance.
• Agrochemical Synthesis: Building block for novel herbicides, fungicides, and insecticides where the fluorine atoms enhance biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Used in the synthesis of fluorinated organic semiconductors and liquid crystal compounds for electronic displays.
• Polymer Modification: Serves as a monomer or modifier to introduce fluorine into polymers, enhancing their chemical resistance, thermal stability, and surface properties.
• Organic Synthesis Reagent: Valuable reagent in cross-coupling reactions and as a precursor for other trifluoromethyl-containing acids, ketones, and amides.
• Fluorinated Surfactant & Coating Precursor: Intermediate for creating surface-active agents and high-performance coatings with low surface energy.

Basic Information

Item	Detail
Product Name	Methyl 3,3,3-Trifluoro-2,2-Dimethylpropanoate
CAS No.	1188911-72-9
Molecular Formula	C6H9F3O2
Molecular Weight	170.13 g/mol
Synonyms	3,3,3-Trifluoro-2,2-dimethylpropanoic Acid Methyl Ester; Methyl 3,3,3-Trifluoro-2,2-dimethylpropionate; 2,2-Dimethyl-3,3,3-trifluoropropionic Acid Methyl Ester; Methyl Trimethylacetate, 3,3,3-Trifluoro Derivative; MTPA Methyl Ester (Trifluoro Derivative); Pivalic Acid, 3,3,3-Trifluoro-, Methyl Ester; Contact for details on additional trade names.
EINECS	Contact for details

Quality Control

Our production of Methyl 3,3,3-Trifluoro-2,2-Dimethylpropanoate adheres to stringent in-process controls and final batch testing to ensure high purity and lot-to-lot consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality system supports compliance with cGMP and ISO 9001 standards for reliable supply to regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases, strong oxidizing agents, and sources of ignition. The container should be kept tightly sealed to prevent moisture absorption and volatilization.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%
Refractive Index (20°C)	1.360 - 1.380
Density (20°C)	1.15 - 1.25 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.