Description

5-Thiazolecarboxylic Acid, 2-Bromo-4-[4-(Trifluoromethyl)Phenyl]-, Ethyl Ester is a high-value, multi-functional heterocyclic building block designed for advanced chemical synthesis. This compound is critical for research and development in pharmaceutical and agrochemical discovery due to its unique molecular architecture, which combines a brominated thiazole core with a trifluoromethylphenyl moiety. It is primarily sought after by medicinal chemists and process development scientists working on novel active ingredients, where it serves as a key intermediate for constructing complex molecules with targeted biological activity.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of novel drug candidates, particularly in oncology, antiviral, and anti-inflammatory research pipelines.
• Agrochemical Development: Used in the research and production of advanced pesticides and herbicides, where the thiazole and trifluoromethyl groups contribute to bioactivity and stability.
• Material Science Research: Serves as a precursor for specialized ligands, organic semiconductors, or functional polymers requiring specific electronic properties.
• Chemical Synthesis: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and other transformations to introduce complex heterocyclic fragments.
• Bioconjugation & Probe Development: Potential use in creating chemical probes or bioconjugates for biochemical and diagnostic applications.

Basic Information

Product Name	5-Thiazolecarboxylic Acid, 2-Bromo-4-[4-(Trifluoromethyl)Phenyl]-, Ethyl Ester
CAS No.	1188153-49-2
Molecular Formula	C13H9BrF3NO2S
Molecular Weight	380.18 g/mol
Synonyms	Ethyl 2-Bromo-4-[4-(trifluoromethyl)phenyl]thiazole-5-carboxylate; 2-Bromo-4-(4-trifluoromethylphenyl)thiazole-5-carboxylic Acid Ethyl Ester; 2-Bromo-4-(α,α,α-trifluoro-p-tolyl)-δ2-thiazoline-5-carboxylic Acid Ethyl Ester; 5-Thiazolecarboxylic acid, 2-bromo-4-[4-(trifluoromethyl)phenyl]-, ethyl ester; 1188153-49-2; Ethyl 2-bromo-4-(4-(trifluoromethyl)phenyl)thiazole-5-carboxylate
EINECS	Contact for details

Quality Control

Our production of 5-Thiazolecarboxylic Acid, 2-Bromo-4-[4-(Trifluoromethyl)Phenyl]-, Ethyl Ester adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot is characterized using advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials. The container must be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 97.0%
Purity (HPLC, Area %)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.