Description

(S)-3-Cyanomethyl-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester is a high-value, chiral pyrrolidine derivative serving as a critical building block in advanced organic synthesis. Its primary value lies in its role as a key intermediate for constructing complex, biologically active molecules, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process development scientists working on new drug candidates, especially in therapeutic areas requiring sophisticated nitrogen-containing heterocycles.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and antiviral drug discovery programs.
• Peptidomimetics & Protease Inhibitors: Used in the construction of peptidomimetic scaffolds and inhibitors targeting various proteases, leveraging the pyrrolidine core's conformational rigidity.
• Ligand & Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis to induce enantioselectivity.
• Agrochemical Synthesis: Employed in the research and development of novel, high-performance pesticides and herbicides that require specific stereochemistry.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for clients.

Basic Information

Product Name	(S)-3-Cyanomethyl-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	1187931-76-5
Molecular Formula	C11H18N2O2
Molecular Weight	210.27 g/mol
Synonyms	1-Boc-3-(cyanomethyl)-(S)-pyrrolidine; (S)-1-(tert-Butoxycarbonyl)-3-(cyanomethyl)pyrrolidine; tert-Butyl (S)-3-(cyanomethyl)pyrrolidine-1-carboxylate; (S)-3-(Cyanomethyl)-1-Boc-pyrrolidine; (S)-1-Boc-3-cyanomethylpyrrolidine; (S)-N-Boc-3-(cyanomethyl)pyrrolidine; (S)-3-Cyanomethyl-1-(tert-butoxycarbonyl)pyrrolidine; (3S)-3-(Cyanomethyl)-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine
EINECS	Contact for details

Quality Control

Our (S)-3-Cyanomethyl-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality control protocols to ensure high chemical and chiral purity, essential for sensitive synthetic applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing specifications for identity, purity (by HPLC), enantiomeric excess (by chiral HPLC), and impurity profiles. We adhere to cGMP principles where applicable, ensuring reliable batch-to-batch consistency and traceability for our global pharmaceutical and research customers.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.