Description

(R)-3,4-Dihydro-2H-Quinoline-1,2-Dicarboxylic Acid 1-tert-Butyl Ester is a high-purity chiral building block and advanced pharmaceutical intermediate of significant synthetic value. This compound is essential for the development of enantiomerically pure active pharmaceutical ingredients (APIs) and complex organic molecules, offering a protected carboxylic acid group and a defined stereocenter for precise chemical transformations. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, agrochemical, and fine chemical sectors for applications in asymmetric synthesis and medicinal chemistry.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of novel drug candidates, particularly in central nervous system (CNS) and oncology research.
• Asymmetric Synthesis: Serves as a precursor for constructing complex, stereodefined heterocyclic frameworks through controlled reactions.
• Protecting Group Chemistry: The tert-butyl ester moiety provides a stable protecting group for the carboxylic acid function, enabling selective deprotection in complex synthetic sequences.
• Medicinal Chemistry & SAR Studies: Used to explore structure-activity relationships by introducing the (R)-configured dihydroquinoline scaffold into target molecules.
• Agrochemical Research: Employed in the development of chiral active ingredients for crop protection agents.
• Catalyst & Ligand Development: Acts as a precursor for synthesizing novel chiral ligands and organocatalysts.

Basic Information

Product Name	(R)-3,4-Dihydro-2H-Quinoline-1,2-Dicarboxylic Acid 1-tert-Butyl Ester
CAS No.	1187931-75-4
Molecular Formula	C15H17NO4
Molecular Weight	275.30 g/mol
Synonyms	(R)-1-(tert-Butoxycarbonyl)-1,2,3,4-tetrahydroquinoline-2-carboxylic acid; (R)-1-Boc-1,2,3,4-tetrahydroquinoline-2-carboxylic acid; (R)-2-Carboxy-1,2,3,4-tetrahydroquinoline-1-carboxylic acid tert-butyl ester; (R)-1-N-Boc-1,2,3,4-tetrahydroquinoline-2-carboxylic acid; (R)-1,2,3,4-Tetrahydroquinoline-1,2-dicarboxylic acid 1-tert-butyl ester; (R)-Boc-Tic-OH (common abbreviation); (R)-Boc-1,2,3,4-tetrahydroquinoline-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our (R)-3,4-Dihydro-2H-Quinoline-1,2-Dicarboxylic Acid 1-tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and production. A detailed Certificate of Analysis (COA) providing batch-specific data for identity, purity, and chiral excess is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.