Description

2-Pyridinemethanamine, .Alpha.-(Trifluoromethyl)-, Hydrochloride (1:1) is a high-value trifluoromethylated pyridine derivative, serving as a critical building block in modern synthetic chemistry. Its core value lies in introducing the metabolically stable and lipophilic trifluoromethyl group, which is essential for modulating the biological activity and physicochemical properties of target molecules. This compound is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, including potential drug candidates and advanced crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances compound stability and efficacy.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science: Employed in the research of advanced organic materials, such as liquid crystals and organic semiconductors, where fluorine substitution tunes electronic properties.
• Chemical Biology Probe Synthesis: Utilized to create labeled compounds and molecular probes for studying biological mechanisms and target engagement.
• Custom Synthesis & Contract Manufacturing: A fundamental starting material for custom synthesis projects and scale-up processes under cGMP or ISO standards.

Basic Information

Product Name	2-Pyridinemethanamine, .Alpha.-(Trifluoromethyl)-, Hydrochloride (1:1)
CAS No.	1187929-38-9
Molecular Formula	C7H8F3N2•HCl
Molecular Weight	216.61 g/mol (Free base: 180.15 g/mol)
Synonyms	α-(Trifluoromethyl)-2-pyridinemethanamine hydrochloride; 1-(2-Pyridinyl)-2,2,2-trifluoroethylamine hydrochloride; 2-(Aminomethyl)-α-(trifluoromethyl)pyridine hydrochloride; (2-Pyridyl)-α-(trifluoromethyl)methylamine HCl; 2-(Trifluoromethyl)aminomethylpyridine hydrochloride; (α-Trifluoromethyl-2-pyridyl)methylamine hydrochloride; 1-(Pyridin-2-yl)-2,2,2-trifluoroethan-1-amine hydrochloride
EINECS	Contact for details

Quality Control

Our 2-Pyridinemethanamine, .Alpha.-(Trifluoromethyl)-, Hydrochloride (1:1) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) with complete analytical data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.