Description

Baricitinib Phosphate Salt is a phosphate salt form of the Janus kinase (JAK) inhibitor Baricitinib, designed to enhance its stability and handling properties. This compound is a critical active pharmaceutical ingredient (API) and a key intermediate in the development and manufacturing of advanced therapeutic agents. It is primarily required by pharmaceutical research institutions, contract development and manufacturing organizations (CDMOs), and API producers focused on immunology and inflammatory diseases.

Application

• Pharmaceutical API Synthesis: Primary use as the active pharmaceutical ingredient in the commercial production of finished dosage forms.
• Research & Development: Serves as a critical reference standard and building block in preclinical and clinical research for JAK inhibitor pathways.
• Formulation Development: Used in the development of solid oral dosage forms (e.g., tablets) due to its salt form's improved physicochemical characteristics.
• Contract Manufacturing: Supplied to CDMOs for the scale-up and cGMP production of drug products targeting autoimmune conditions.
• Biochemical Research: Utilized in vitro and in vivo studies to investigate JAK-STAT signaling mechanisms and therapeutic efficacy.

Basic Information

Product Name	Baricitinib Phosphate Salt
CAS No.	1187595-84-1
Molecular Formula	C16H17N7O2 · H3PO4
Molecular Weight	465.36 g/mol (free base: 371.40 g/mol)
Synonyms	Baricitinib phosphate; Baricitinib phosphoric acid salt; INCB028050 phosphate; (R)-Baricitinib phosphate; 2-[1-(Ethylsulfonyl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]azetidin-3-yl]acetonitrile phosphate; LY3009104 phosphate; Olumiant® (brand name drug) phosphate salt
EINECS	Contact for details

Quality Control

Our Baricitinib Phosphate Salt is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and impurity profiles. We support compliance with ICH guidelines and relevant pharmacopeial standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0% (anhydrous basis)
Water Content (KF)	≤2.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0%
Single Unknown Impurity	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.