Description

Baricitinib is a potent and selective Janus kinase (JAK) inhibitor, a critical active pharmaceutical ingredient (API) in modern therapeutics. Its primary value lies in modulating immune and inflammatory signaling pathways, offering targeted treatment options. This compound is essential for pharmaceutical manufacturers and research institutions developing advanced therapies for autoimmune and inflammatory conditions.

Application

• Pharmaceutical API: Primary use as the active ingredient in prescription medications for rheumatoid arthritis, alopecia areata, and other autoimmune disorders.
• Clinical Research: Serves as a key reference standard and investigational compound in immunological and inflammatory disease research.
• Drug Formulation Development: Used in the R&D of solid oral dosage forms, such as tablets and capsules, requiring high-purity API.
• Biochemical Research: A tool compound for studying JAK-STAT signaling pathways in cellular and molecular biology.
• Generic Drug Manufacturing: Critical for companies producing bioequivalent versions of branded JAK inhibitor therapies.
• Preclinical Studies: Utilized in pharmacokinetic, pharmacodynamic, and toxicology studies during drug development.

Basic Information

Product Name	Baricitinib
CAS No.	1187594-09-7
Molecular Formula	C16H17N7O2S
Molecular Weight	371.42 g/mol
Synonyms	Baricitinib; INCB028050; LY3009104; 2-[(1-Ethylsulfonyl-3H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-4-(4-methylpiperazin-1-yl)pyrimidine-5-carbonitrile; Olumiant (Brand Name); JAK1/JAK2 Inhibitor
EINECS	Contact for details

Quality Control

Our Baricitinib is manufactured under strict quality management systems, targeting purity levels suitable for pharmaceutical applications. Each batch is subjected to comprehensive analytical testing, including HPLC for assay and related substances, residual solvent analysis, and identification by spectroscopic methods. A Certificate of Analysis (COA) is provided with every shipment, detailing compliance with agreed specifications. We support development and commercial projects requiring adherence to ICH guidelines and cGMP standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5%
Related Substances (HPLC)	Total impurities ≤1.5%; Any single unknown impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.