Description

1-(5-Bromopyridin-2-Yl)Piperazine, HCl is a high-purity, halogenated piperazine derivative serving as a critical building block in modern synthetic chemistry. This compound is essential for researchers and manufacturers requiring a reliable, high-quality intermediate to accelerate drug discovery and material science projects. It is primarily utilized by pharmaceutical R&D teams and fine chemical producers engaged in developing novel active pharmaceutical ingredients (APIs) and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of complex molecules targeting central nervous system (CNS) disorders, oncology, and other therapeutic areas.
• Ligand & Catalyst Development: Used in the preparation of specialized ligands for metal-catalyzed cross-coupling reactions, such as Buchwald-Hartwig amination.
• Agrochemical Research: Serves as a precursor in the development of new crop protection agents and herbicides.
• Material Science: Employed in the creation of advanced polymers and organic electronic materials due to its piperazine and pyridine motifs.
• Chemical Biology Probes: Useful for constructing molecular probes and tool compounds for studying biological pathways and protein interactions.
• Custom Synthesis & Scale-Up: Available for contract manufacturing organizations (CMOs) and companies requiring custom synthesis from gram to kilogram scale.

Basic Information

Product Name	1-(5-Bromopyridin-2-Yl)Piperazine, HCl
CAS No.	1187386-40-8
Molecular Formula	C9H13BrClN3
Molecular Weight	278.58 g/mol
Synonyms	1-(5-Bromo-2-pyridinyl)piperazine hydrochloride; 5-Bromo-2-(piperazin-1-yl)pyridine hydrochloride; 1-(5-Bromopyridin-2-yl)piperazine hydrochloride; 2-(1-Piperazinyl)-5-bromopyridine hydrochloride; 5-Bromo-2-piperazin-1-ylpyridine hydrochloride; 1187386-40-8; 1-(5-Bromopyridin-2-yl)piperazine HCl
EINECS	Contact for details

Quality Control

Our 1-(5-Bromopyridin-2-Yl)Piperazine, HCl is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles, typically determined by HPLC, NMR, and mass spectrometry. We adhere to cGMP principles for pharmaceutical-grade intermediates, ensuring reliable supply and traceability for critical R&D and production applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.