Description

5-(2,3-Difluorobenzoyl)-2-Methylpyridine is a high-purity, specialized organic intermediate featuring a difluorobenzoyl moiety attached to a methylpyridine core. This compound is valued for its role as a critical building block in the synthesis of advanced pharmaceutical and agrochemical agents, where its specific fluorine substitution pattern is essential for modulating biological activity and physicochemical properties. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for creating novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and inflammatory diseases.
• Agrochemical Research: Serves as a building block for developing new generation herbicides, fungicides, and insecticides, leveraging fluorine chemistry to enhance efficacy and environmental profile.
• Ligand Synthesis: Used in the preparation of specialized ligands for catalysis and metal-organic frameworks (MOFs) in material science applications.
• Fluorinated Compound Library: An essential component for constructing diverse fluorinated compound libraries in medicinal chemistry for high-throughput screening and structure-activity relationship (SAR) studies.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme mechanisms and biological pathways.

Basic Information

Product Name	5-(2,3-Difluorobenzoyl)-2-Methylpyridine
CAS No.	1187164-84-6
Molecular Formula	C14H9F2NO
Molecular Weight	245.23 g/mol
Synonyms	2-Methyl-5-(2,3-difluorobenzoyl)pyridine; 5-(2,3-Difluorobenzoyl)-2-picoline; (2,3-Difluorophenyl)(6-methylpyridin-3-yl)methanone; 2,3-Difluoro-6-methyl-3-pyridinyl phenyl ketone; 3-Pyridinecarboxylic acid, 6-methyl-, 2,3-difluorophenyl ester (tautomer); 1187164-84-6; 5-(2,3-Difluorobenzoyl)-2-methylpyridine
EINECS	Contact for details

Quality Control

Our 5-(2,3-Difluorobenzoyl)-2-Methylpyridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.