Description

5-(2,4-Difluorobenzoyl)-2-Methylpyridine is a high-purity fluorinated pyridine derivative, serving as a critical advanced intermediate in modern synthetic chemistry. Its value lies in its unique molecular scaffold, which is designed to introduce specific fluorinated aromatic and heterocyclic motifs into target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical sectors who require reliable, high-quality building blocks for drug discovery and active ingredient development.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and fungicides, where the difluorobenzoyl group can enhance biological activity and environmental stability.
• Material Science Research: Serves as a precursor for creating specialized ligands, fluorinated liquid crystals, or functional polymers with tailored properties.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme function and cellular pathways.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences industry.

Basic Information

Product Name	5-(2,4-Difluorobenzoyl)-2-Methylpyridine
CAS No.	1187164-35-7
Molecular Formula	C13H9F2NO
Molecular Weight	233.21 g/mol
Synonyms	2-Methyl-5-(2,4-difluorobenzoyl)pyridine; 5-(2,4-Difluorobenzoyl)-2-picoline; 2-Picoline, 5-(2,4-difluorobenzoyl)-; (2,4-Difluorophenyl)(6-methylpyridin-3-yl)methanone; 3-Pyridinecarboxylic acid, 6-methyl-, 2,4-difluorophenyl ketone
EINECS	Contact for details

Quality Control

Our production of 5-(2,4-Difluorobenzoyl)-2-Methylpyridine adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) with every shipment, confirming compliance with client specifications and cGMP standards where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from heat sources and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any single impurity ≤ 0.5%, Total impurities ≤ 1.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.