Description

Carbamic Acid, n-[4-[(1R,3S)-3-Methyl-5-Oxocyclohexyl]-3-Pyridinyl]-, Phenylmethyl Ester, Rel- is a high-purity chiral intermediate of significant importance in advanced pharmaceutical synthesis. This compound matters for its role as a key building block in the development of novel active pharmaceutical ingredients (APIs), particularly those targeting complex therapeutic areas. Pharmaceutical R&D teams and fine chemical manufacturers need this material for its precise stereochemistry and functional groups, which are critical for constructing molecules with specific biological activity.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral synthon in the multi-step synthesis of proprietary drug candidates.
• API Development: Used in research and process development for new Active Pharmaceutical Ingredients, especially in oncology and central nervous system (CNS) therapeutic areas.
• Process Chemistry: Employed in route scouting and optimization studies within medicinal and process chemistry laboratories.
• Asymmetric Synthesis: Utilized in reactions requiring high enantiomeric purity due to its defined (1R,3S) relative configuration.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP production of clinical trial materials.
• Academic Research: Used in university and institutional labs for methodological studies in organic and medicinal chemistry.

Basic Information

Product Name	Carbamic Acid, n-[4-[(1R,3S)-3-Methyl-5-Oxocyclohexyl]-3-Pyridinyl]-, Phenylmethyl Ester, Rel-
CAS No.	1187056-01-4
Molecular Formula	C20H22N2O3
Molecular Weight	338.40 g/mol
Synonyms	Benzyl N-[4-[(1R,3S)-3-methyl-5-oxocyclohexyl]pyridin-3-yl]carbamate; Rel-(1R,3S)-Benzyl (4-(3-methyl-5-oxocyclohexyl)pyridin-3-yl)carbamate; (1R,3S)-3-Methyl-5-oxo-1-(3-(((phenylmethoxy)carbonyl)amino)pyridin-4-yl)cyclohexanecarboxylic acid (related); Carbamic acid, N-[4-[(1R,3S)-3-methyl-5-oxo-1-cyclohexyl]-3-pyridinyl]-, phenylmethyl ester; UNII-Contact for details; BRN-Contact for details; Chiral Cyclohexanone Pyridine Carbamate Intermediate.
EINECS	Contact for details

Quality Control

Our Carbamic Acid, n-[4-[(1R,3S)-3-Methyl-5-Oxocyclohexyl]-3-Pyridinyl]-, Phenylmethyl Ester, Rel- is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure identity, purity, and stereochemical integrity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our quality standards are designed to meet the stringent requirements of pharmaceutical R&D and can be aligned with cGMP guidelines for advanced applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% de
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.