Description

Methyl 5-Hydroxypiperidine-3-Carboxylate Hydrochloride is a high-purity pharmaceutical intermediate and building block of significant importance in modern organic synthesis. Its value lies in its functionalized piperidine scaffold, which is a privileged structure in medicinal chemistry for constructing bioactive molecules. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of new therapeutic agents, particularly within the fields of central nervous system (CNS) and metabolic disorder research.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of novel drug candidates targeting various disease pathways.
• Medicinal Chemistry Research: Used in hit-to-lead optimization and structure-activity relationship (SAR) studies due to its versatile piperidine core.
• API Synthesis: Serves as a precursor in the multi-step synthesis of Active Pharmaceutical Ingredients (APIs), especially those containing functionalized heterocycles.
• Chemical Biology Probes: Employed in the development of molecular probes and tool compounds for studying biological mechanisms and target validation.
• Asymmetric Synthesis: Utilized as a starting material or intermediate in chiral synthesis, leveraging its stereogenic centers.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and process development services.

Basic Information

Product Name	Methyl 5-Hydroxypiperidine-3-Carboxylate Hydrochloride
CAS No.	1186663-43-3
Molecular Formula	C8H15NO3 • HCl
Molecular Weight	209.67 g/mol (Free base: 173.21 g/mol)
Synonyms	Methyl 5-hydroxypiperidine-3-carboxylate hydrochloride; 5-Hydroxypiperidine-3-carboxylic acid methyl ester hydrochloride; 3-Piperidinecarboxylic acid, 5-hydroxy-, methyl ester, hydrochloride; Methyl 5-hydroxynipecotate hydrochloride; 5-Hydroxy-3-(methoxycarbonyl)piperidine hydrochloride
EINECS	Contact for details

Quality Control

Our Methyl 5-Hydroxypiperidine-3-Carboxylate Hydrochloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity, purity, and the absence of critical impurities. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after each use to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.