Description

[2-(2,2-Dimethyl-Propionylamino)-Pyridin-3-Yl]-Carbamic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate designed for the synthesis of complex active pharmaceutical ingredients (APIs). This compound matters because it offers a critical building block for medicinal chemists, enabling the development of novel therapeutic agents with precise structural control. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in drug discovery and process development for new chemical entities.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of novel small-molecule drug candidates, particularly in oncology and central nervous system (CNS) research.
• API Synthesis: Used as a protected amino-pyridine derivative for constructing complex molecular architectures in Active Pharmaceutical Ingredient (API) manufacturing.
• Medicinal Chemistry Research: Serves as a versatile scaffold in structure-activity relationship (SAR) studies and lead optimization programs within R&D laboratories.
• Process Chemistry Development: Employed in scaling up synthetic routes from milligram to kilogram scale, supporting clinical trial material production.
• Custom Synthesis Building Block: Utilized by fine chemical suppliers for the custom synthesis of proprietary compounds under contract research and manufacturing (CRAM) agreements.

Basic Information

Product Name	[2-(2,2-Dimethyl-Propionylamino)-Pyridin-3-Yl]-Carbamic Acid tert-Butyl Ester
CAS No.	1186311-23-8
Molecular Formula	C15H23N3O3
Molecular Weight	293.36 g/mol
Synonyms	tert-Butyl N-[2-[(2,2-dimethylpropanoyl)amino]-3-pyridyl]carbamate; 2-[(2,2-Dimethylpropanoylamino)pyridin-3-yl]carbamic acid tert-butyl ester; tert-Butyl (2-(pivalamido)pyridin-3-yl)carbamate; 3-((tert-Butoxycarbonyl)amino)-2-pivalamidopyridine; BOC-Protected 2-Amino-3-Pivalamidopyridine; (2-Pivalamidopyridin-3-yl)carbamic acid tert-butyl ester; N-BOC-2-Pivalamido-3-aminopyridine
EINECS	Contact for details

Quality Control

Our [2-(2,2-Dimethyl-Propionylamino)-Pyridin-3-Yl]-Carbamic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure compliance with exacting standards for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.