Description

2-(Trimethylsilyl)Furo[3,2-B]Pyridin-6-Ol is a high-purity, advanced heterocyclic building block featuring a fused furopyridine core modified with a trimethylsilyl protecting group. This compound is critical for medicinal chemistry and pharmaceutical research, serving as a versatile intermediate in the synthesis of complex bioactive molecules. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing novel drug candidates and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of potential active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and central nervous system (CNS) drug discovery programs.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies due to its fused heterocyclic scaffold, which can modulate drug-like properties.
• Agrochemical Synthesis: Intermediate in the development of novel herbicides, fungicides, and insecticides that require complex heterocyclic architectures.
• Material Science Precursor: Serves as a specialty monomer or ligand precursor in the development of advanced organic electronic materials and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme function and biological pathways.

Basic Information

Product Name	2-(Trimethylsilyl)Furo[3,2-B]Pyridin-6-Ol
CAS No.	1186310-90-6
Molecular Formula	C13H17NO2Si
Molecular Weight	247.37 g/mol
Synonyms	6-Hydroxy-2-(trimethylsilyl)furo[3,2-b]pyridine; 2-(Trimethylsilyl)-6-hydroxyfuro[3,2-b]pyridine; Furo[3,2-b]pyridin-6-ol, 2-(trimethylsilyl)-; TMS-Furopyridinol; 1186310-90-6; 2-TMS-furo[3,2-b]pyridin-6-ol
EINECS	Contact for details

Quality Control

Every batch of 2-(Trimethylsilyl)Furo[3,2-B]Pyridin-6-Ol is manufactured and tested under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation, meeting the stringent requirements for research and process chemistry. Certificates of Analysis (COA) with full analytical data are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.