Description

n-(3-((3-((tert-Butyldimethylsilyloxy)Methyl)Pyrrolidin-1-Yl)Methyl)-2-Chloropyridin-4-Yl)Pivalamide is a sophisticated, high-purity chemical intermediate featuring a protected hydroxyl group and a pivalamide moiety. This compound is critical for pharmaceutical research and development, offering a versatile building block for the synthesis of complex active pharmaceutical ingredients (APIs). It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology sectors for constructing novel drug candidates.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug molecules, particularly in medicinal chemistry programs.
• API Synthesis: Used in the research and process development stages for creating new Active Pharmaceutical Ingredients (APIs).
• Protecting Group Chemistry: The tert-butyldimethylsilyl (TBDMS) group serves as a protective moiety for the hydroxyl function during multi-step synthetic sequences.
• Heterocyclic Compound Synthesis: The pyrrolidine and chloropyridine structures make it valuable for constructing nitrogen-containing heterocycles with biological activity.
• Process Chemistry & Scale-up: Suitable for optimization from laboratory-scale research to pilot plant and commercial manufacturing processes.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	n-(3-((3-((tert-Butyldimethylsilyloxy)Methyl)Pyrrolidin-1-Yl)Methyl)-2-Chloropyridin-4-Yl)Pivalamide
CAS No.	1186310-83-7
Molecular Formula	C22H38ClN3O2Si
Molecular Weight	440.10 g/mol
Synonyms	Pivalamide, N-[3-[[3-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]methyl]-1-pyrrolidinyl]methyl]-2-chloro-4-pyridinyl]-; 2-Chloro-N-(3-((3-(((tert-butyldimethylsilyl)oxy)methyl)pyrrolidin-1-yl)methyl)pyridin-4-yl)pivalamide; 1186310-83-7; TBDMS-protected pyrrolidine-chloropyridine pivalamide; 4-Pyridinepivalamide, 2-chloro-3-((3-(((1,1-dimethylethyl)dimethylsilyl)oxy)methyl)-1-pyrrolidinyl)methyl]-
EINECS	Contact for details

Quality Control

Our n-(3-((3-((tert-Butyldimethylsilyloxy)Methyl)Pyrrolidin-1-Yl)Methyl)-2-Chloropyridin-4-Yl)Pivalamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and structural identity. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are provided to support your R&D and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.