Description

6-Chloro-2-(Trimethylsilyl)Furo[3,2-B]Pyridine is a high-value, organosilicon-substituted heterocyclic building block of significant interest in advanced organic synthesis. Its unique fused-ring structure, featuring both a halogen and a silyl protecting group, makes it a versatile intermediate for constructing complex molecular architectures. This compound is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders and oncology.
• Agrochemical Research: Used in the development of new pesticides and herbicides, where its heterocyclic core can contribute to biological activity.
• Material Science: Acts as a specialized monomer or additive in the research of advanced polymers and organic electronic materials.
• Cross-Coupling Reactions: The chloro substituent makes it a suitable substrate for palladium-catalyzed reactions like Suzuki, Negishi, or Buchwald-Hartwig amination.
• Organometallic Chemistry: The trimethylsilyl group can be utilized for further functionalization or as a directing/protecting group in complex synthetic sequences.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying biological systems and enzyme mechanisms.

Basic Information

Product Name	6-Chloro-2-(Trimethylsilyl)Furo[3,2-B]Pyridine
CAS No.	1186310-77-9
Molecular Formula	C12H14ClNOSi
Molecular Weight	251.78 g/mol
Synonyms	6-Chloro-2-(trimethylsilyl)furo[3,2-b]pyridine; 2-(Trimethylsilyl)-6-chlorofuro[3,2-b]pyridine; Furo[3,2-b]pyridine, 6-chloro-2-(trimethylsilyl)-; 1186310-77-9; 6-Chloro-2-trimethylsilylfuro[3,2-b]pyridine
EINECS	Contact for details

Quality Control

Our 6-Chloro-2-(Trimethylsilyl)Furo[3,2-B]Pyridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with customer specifications and industry best practices for research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/GC)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.