Description

6-Iodo-2-(Trimethylsilyl)Furo[3,2-B]Pyridine is a high-value, multi-functional heterocyclic building block featuring both an iodine and a trimethylsilyl protecting group. This compound is specifically engineered for advanced synthetic chemistry, offering versatile reactivity for cross-coupling reactions and serving as a key intermediate in complex molecular construction. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for the development of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors and other heterocyclic-based therapeutics.
• Agrochemical Research: Used in the development of new active ingredients for crop protection, leveraging its structural complexity for enhanced biological activity.
• Material Science: Serves as a precursor for organic electronic materials, including ligands for OLEDs and other optoelectronic devices.
• Cross-Coupling Reactions: The iodine moiety makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, and Negishi couplings for carbon-carbon bond formation.
• Protecting Group Strategy: The trimethylsilyl group can be used for temporary protection of sensitive sites during multi-step synthetic sequences.
• Academic & Contract Research: A valuable reagent for methodological development and the synthesis of complex natural product analogs in university and CRO laboratories.

Basic Information

Product Name	6-Iodo-2-(Trimethylsilyl)Furo[3,2-B]Pyridine
CAS No.	1186310-73-5
Molecular Formula	C₁₀H₁₂INOSi
Molecular Weight	333.20 g/mol
Synonyms	2-(Trimethylsilyl)-6-iodofuro[3,2-b]pyridine; Furo[3,2-b]pyridine, 6-iodo-2-(trimethylsilyl)-; 6-Iodo-2-trimethylsilylfuro[3,2-b]pyridine; TMS-Iodo-Furopyridine; Iodo-TMS-Furopyridine Intermediate
EINECS	Contact for details

Quality Control

Every batch of 6-Iodo-2-(Trimethylsilyl)Furo[3,2-B]Pyridine is manufactured and tested under strict quality management protocols to ensure consistency and reliability for critical research and development applications. Our standard quality commitment includes comprehensive analysis via HPLC, NMR (¹H and ¹³C), and mass spectrometry to confirm identity and purity. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Handle and store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.