Description

2-(Azetidin-3-Yloxy)-5-Bromopyridine Hydrochloride is a high-purity, advanced pharmaceutical intermediate characterized by its unique heterocyclic structure. This compound is of significant value in medicinal chemistry for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of new therapeutic agents, particularly within oncology and central nervous system (CNS) drug discovery pipelines.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of complex drug candidates, especially those targeting specific biological receptors.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization to develop new molecules with improved efficacy and safety profiles.
• API Development: Serves as a core scaffold for constructing novel active pharmaceutical ingredients in pre-clinical and clinical development stages.
• Chemical Biology Probes: Utilized in the creation of specialized molecular probes for studying enzyme function and cellular pathways.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and process development services for the global pharmaceutical industry.

Basic Information

Product Name	2-(Azetidin-3-Yloxy)-5-Bromopyridine Hydrochloride
CAS No.	1186234-53-6
Molecular Formula	C8H10BrClN2O
Molecular Weight	265.53 g/mol
Synonyms	5-Bromo-2-(3-azetidinyloxy)pyridine hydrochloride; 2-(Azetidin-3-yloxy)-5-bromopyridine HCl; 5-Bromo-2-(azetidin-3-yloxy)pyridine hydrochloride; 2-(Azetidin-3-yloxy)-5-bromopyridinium chloride; Azetidine, 3-[(5-bromo-2-pyridinyl)oxy]-, hydrochloride (1:1); 3-[(5-Bromopyridin-2-yl)oxy]azetidine hydrochloride
EINECS	Contact for details

Quality Control

Our 2-(Azetidin-3-Yloxy)-5-Bromopyridine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with customer specifications and relevant ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.