Description

Ethyl 4-Bromo-2-(Trifluoromethoxy)Benzoate is a high-value, multi-functional organic building block characterized by its bromo and trifluoromethoxy substituents. This compound is essential for advanced organic synthesis, offering a versatile handle for cross-coupling reactions and the introduction of fluorine-containing motifs. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring fluorinated aromatic systems for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the trifluoromethoxy group imparts unique biological activity.
• Material Science Research: Serves as a precursor for specialty polymers, liquid crystals, and organic electronic materials due to its halogen and fluorine content.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed coupling reactions to construct complex biaryl structures.
• Chemical Biology & Medicinal Chemistry: Employed in fragment-based drug discovery and as a probe molecule for studying biological targets.
• Custom Synthesis & Contract Manufacturing: A critical starting material for fine chemical manufacturers offering bespoke synthesis services to the life sciences sector.

Basic Information

Product Name	Ethyl 4-Bromo-2-(Trifluoromethoxy)Benzoate
CAS No.	1186195-27-6
Molecular Formula	C10H8BrF3O3
Molecular Weight	313.07 g/mol
Synonyms	4-Bromo-2-(trifluoromethoxy)benzoic acid ethyl ester; Ethyl 4-bromo-2-(trifluoromethoxy)benzoate; Benzoic acid, 4-bromo-2-(trifluoromethoxy)-, ethyl ester; 4-Bromo-2-(trifluoromethoxy)benzoic acid ethyl ester; Ethyl 4-bromo-α,α,α-trifluoro-o-anisate; 1186195-27-6; SCHEMBL23305577
EINECS	Contact for details

Quality Control

Our Ethyl 4-Bromo-2-(Trifluoromethoxy)Benzoate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most sensitive applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). The product should be kept away from strong bases and incompatible materials. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Standard Grade)
Purity (GC)	≥97.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.