Description

tert-Butyl 8-Methoxy-1,3,4,5-Tetrahydro-2H-Pyrido[4,3-B]Indole-2-Carboxylate is a high-value, protected heterocyclic building block essential for advanced organic synthesis. This compound serves as a critical intermediate in the development of complex pharmaceutical molecules, particularly those targeting neurological and psychiatric disorders. It is primarily utilized by research institutions and pharmaceutical companies engaged in medicinal chemistry and process development for new active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, especially those with indole and tetrahydro-β-carboline scaffolds.
• Medicinal Chemistry Research: Used as a versatile building block for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Neurological Drug Development: Integral to the synthesis of compounds targeting serotonin and dopamine receptors for potential treatments of depression, anxiety, and Parkinson's disease.
• Process Chemistry & Scale-up: Employed in route scouting and optimization for the commercial-scale manufacturing of complex APIs.
• Chemical Biology Probes: Serves as a core structure for developing molecular probes to study enzyme function and biological pathways.
• Custom Synthesis: Starting material for the contract manufacturing of specialized, non-commercial chemical entities for clinical trials.

Basic Information

Product Name	tert-Butyl 8-Methoxy-1,3,4,5-Tetrahydro-2H-Pyrido[4,3-B]Indole-2-Carboxylate
CAS No.	1186099-85-3
Molecular Formula	C17H22N2O3
Molecular Weight	302.37 g/mol
Synonyms	8-Methoxy-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxylic acid tert-butyl ester; tert-Butyl 8-methoxy-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole-2-carboxylate; 2H-Pyrido[4,3-b]indole-2-carboxylic acid, 1,3,4,5-tetrahydro-8-methoxy-, 1,1-dimethylethyl ester; 8-Methoxy-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole-2-carboxylic acid tert-butyl ester; tert-Butyl 8-methoxy-1,2,3,4-tetrahydro-5H-pyrido[4,3-b]indole-2-carboxylate
EINECS	Contact for details

Quality Control

Our tert-Butyl 8-Methoxy-1,3,4,5-Tetrahydro-2H-Pyrido[4,3-B]Indole-2-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with each shipment. We support development and cGMP-grade requirements for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if necessary for long-term storage.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.