Description

4-Hydroxy-3,4,5,6-Tetrahydro-2H-[1,2']Bipyridinyl-3'-Carboxylic Acid Methyl Ester Hydrochloride is a high-purity, advanced pharmaceutical intermediate with a complex bicyclic structure. This compound is critical for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated molecular scaffolds. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of new drug candidates, especially within medicinal chemistry and process R&D.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug molecules, particularly for central nervous system (CNS) and other targeted therapies.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new chemical entities.
• Process Chemistry Development: Serves as a critical intermediate for scaling up synthetic routes from laboratory to pilot plant and commercial production.
• Contract Research & Manufacturing (CRAM): Supplied to organizations specializing in custom synthesis and development services for the pharmaceutical industry.
• Academic Research: Employed in university and institutional labs for studying heterocyclic chemistry and developing new synthetic methodologies.

Basic Information

Product Name	4-Hydroxy-3,4,5,6-Tetrahydro-2H-[1,2']Bipyridinyl-3'-Carboxylic Acid Methyl Ester Hydrochloride
CAS No.	1185318-75-5
Molecular Formula	C12H17ClN2O3
Molecular Weight	272.73 g/mol
Synonyms	Methyl 4-hydroxy-3,4,5,6-tetrahydro-2H-[1,2'-bipyridine]-3'-carboxylate hydrochloride; 2H-[1,2']Bipyridinyl-3'-carboxylic acid, 4-hydroxy-3,4,5,6-tetrahydro-, methyl ester, hydrochloride; Methyl 4-hydroxypiperidinopyridine-3-carboxylate hydrochloride; Bicyclic piperidinopyridine ester hydrochloride
EINECS	Contact for details

Quality Control

Our production of 4-Hydroxy-3,4,5,6-Tetrahydro-2H-[1,2']Bipyridinyl-3'-Carboxylic Acid Methyl Ester Hydrochloride adheres to stringent quality management protocols. Each batch is subjected to comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications and test results are provided and available upon request. We support development under cGMP guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.