Description

3-Chloro-4-(3-Pyridinyloxy)Aniline Dihydrochloride is a high-purity, advanced pharmaceutical intermediate of significant commercial and research interest. Its core value lies in its role as a critical building block for the synthesis of complex active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated heterocyclic chemistry. This compound is essential for R&D chemists and process development scientists in the pharmaceutical and fine chemical industries, where precise molecular construction is paramount. The CAS number for this compound is provided in the table below.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting kinase inhibition or other receptor-based therapies.
• Agrochemical Research: Used in the development of new herbicides or pesticides, leveraging its aniline and pyridine motifs.
• Material Science: Serves as a monomer or functionalizing agent in the creation of specialty polymers and advanced organic materials.
• Chemical Synthesis: Employed in academic and industrial laboratories for constructing complex heterocyclic frameworks and for methodological studies in organic chemistry.
• Bioconjugation: The aniline group can be utilized for coupling reactions in the development of antibody-drug conjugates (ADCs) or diagnostic probes.

Basic Information

Product Name	3-Chloro-4-(3-Pyridinyloxy)Aniline Dihydrochloride
CAS No.	1185304-58-8
Molecular Formula	C11H10ClN2O·2HCl
Molecular Weight	295.58 g/mol (Free base: 221.67 g/mol)
Synonyms	3-Chloro-4-(pyridin-3-yloxy)aniline dihydrochloride; 4-Amino-2-chloro-1-(3-pyridinyloxy)benzene dihydrochloride; 3-Chloro-4-(3-pyridyloxy)aniline hydrochloride (1:2); 3-Pyridinyloxy-4-chloroaniline dihydrochloride; Benzenamine, 3-chloro-4-(3-pyridinyloxy)-, dihydrochloride
EINECS	Contact for details

Quality Control

Every batch of 3-Chloro-4-(3-Pyridinyloxy)Aniline Dihydrochloride is produced and tested under a strict quality management system. We employ advanced analytical techniques including HPLC, NMR, and mass spectrometry to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and residual solvents is provided with each shipment, supporting compliance in cGMP and ISO 9001 environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%; Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.