Description

1-(4-Methylamino-2-Piperidin-3-Yl-7,8-Dihydro-5H-Pyrido[4,3-D]Pyrimidin-6-Yl)-Ethanone Dihydrochloride is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is of significant value in medicinal chemistry research and development, particularly for its role as a key building block in the synthesis of targeted therapeutic agents. It is primarily required by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of novel drug candidates, especially within oncology and central nervous system (CNS) therapeutic areas.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of active pharmaceutical ingredients (APIs) for preclinical and clinical studies.
• Medicinal Chemistry Research: Used as a scaffold or building block for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Kinase Inhibitor Development: Its pyrido[4,3-d]pyrimidine core is a privileged structure in the design of potent and selective kinase inhibitors for cancer therapy.
• Chemical Biology Probes: Utilized in the development of tool compounds for probing specific biological pathways and target validation.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and process development services for the pharmaceutical industry.
• Academic Research: Employed in university and institutional labs for cutting-edge research in organic synthesis and pharmacology.

Basic Information

Product Name	1-(4-Methylamino-2-Piperidin-3-Yl-7,8-Dihydro-5H-Pyrido[4,3-D]Pyrimidin-6-Yl)-Ethanone Dihydrochloride
CAS No.	1185295-49-1
Molecular Formula	C16H25N5O • 2HCl
Molecular Weight	384.33 g/mol (Free base: 303.41 g/mol)
Synonyms	1-(4-(Methylamino)-2-(piperidin-3-yl)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl)ethanone dihydrochloride; 1-[4-(Methylamino)-2-piperidin-3-yl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]ethanone dihydrochloride; UNII-9J2F11C8D2; 9J2F11C8D2; Ethanone, 1-[4-(methylamino)-2-(3-piperidinyl)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]-, dihydrochloride
EINECS	Contact for details

Quality Control

Our 1-(4-Methylamino-2-Piperidin-3-Yl-7,8-Dihydro-5H-Pyrido[4,3-D]Pyrimidin-6-Yl)-Ethanone Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for pharmaceutical research. Certificates of Analysis (COA) detailing purity (typically ≥95% by HPLC), identity confirmation (by NMR, MS, and IR), and impurity profiles are provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a dry environment and handled under conditions that minimize exposure to ambient light and humidity to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.