Description

2-[(2-Azidoethoxy-D4)Methyl]-4-(2-Chlorophenyl)-3-Ethoxycarbonyl-5-Methoxycarbonyl)-6-Methyl-1,4-Dihydropyridine is a deuterated and azide-functionalized 1,4-dihydropyridine derivative, a sophisticated building block of significant interest in advanced chemical synthesis. Its core value lies in its dual functionality, serving as a versatile precursor for click chemistry via the azide group while the deuterium labeling provides a critical tool for pharmacokinetic and metabolic studies. This compound is essential for pharmaceutical R&D teams, medicinal chemists, and contract research organizations (CROs) engaged in developing novel therapeutics, particularly in the areas of cardiovascular and neurological drug discovery.

Application

• Pharmaceutical Intermediate: Key synthetic precursor for the development of deuterated drug candidates, enhancing metabolic stability and bioavailability.
• Click Chemistry Reagent: The azidoethoxy moiety enables efficient, selective conjugation with alkynes via copper-catalyzed azide-alkyne cycloaddition (CuAAC) for bioconjugation and probe synthesis.
• Isotope Labeling Standard: Used as an internal standard in LC-MS and GC-MS for the accurate quantification of non-deuterated analogs in complex biological matrices.
• Medicinal Chemistry Research: A critical scaffold for structure-activity relationship (SAR) studies in 1,4-dihydropyridine-based calcium channel modulators.
• Proteomics & Chemical Biology: Facilitates the creation of activity-based probes for target identification and protein labeling studies.
• Process Chemistry Development: Employed in route scouting and optimization for the scalable synthesis of complex active pharmaceutical ingredients (APIs).

Basic Information

Item	Details
Product Name	2-[(2-Azidoethoxy-D4)Methyl]-4-(2-Chlorophenyl)-3-Ethoxycarbonyl-5-Methoxycarbonyl)-6-Methyl-1,4-Dihydropyridine
CAS No.	1185133-69-0
Molecular Formula	C₂₁H₂₀D₄ClN₃O₆ *
Molecular Weight	Approx. 461.91 g/mol *
Synonyms	1,4-Dihydropyridine-3,5-dicarboxylic acid, 2-[(2-azidoethoxy-d4)methyl]-4-(2-chlorophenyl)-6-methyl-, 3-ethyl 5-methyl ester; Deuterated Azido-DHP; 2-(2-Azidoethoxy-d4-methyl)-DHP derivative; 4-(2-Chlorophenyl)-DHP azide-d4; CAS 1185133-69-0; Azide-functionalized deuterated DHP ester; 1,4-DHP click chemistry reagent-d4.
EINECS	Contact for details

* Calculated values. Contact us for confirmed analytical data.

Quality Control

Every batch of our 2-[(2-Azidoethoxy-D4)Methyl]-4-(2-Chlorophenyl)-3-Ethoxycarbonyl-5-Methoxycarbonyl)-6-Methyl-1,4-Dihydropyridine is manufactured under strict quality management systems. We employ advanced analytical techniques including NMR (¹H, ¹³C), HPLC, and LC-MS to ensure high chemical purity, isotopic enrichment, and structural integrity. A comprehensive Certificate of Analysis (COA) detailing purity, assay, deuterium incorporation, and impurity profile is provided with each shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. This compound is both light-sensitive and may be hygroscopic; allow the sealed container to equilibrate to room temperature before opening to minimize moisture ingress. Keep away from strong oxidizing agents and sources of heat.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Deuterium Incorporation (MS)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.