Description

4-Chloro-2-Fluoro-5-Iodopyridine is a highly functionalized pyridine derivative that serves as a critical multi-halogenated building block in advanced organic synthesis. Its unique combination of chlorine, fluorine, and iodine substituents on the pyridine ring makes it an exceptionally versatile intermediate for constructing complex molecular architectures. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications such as cross-coupling reactions, nucleophilic aromatic substitution, and the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system disorders, oncology, and infectious diseases.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, leveraging the halogenated pyridine core for bioactivity.
• Cross-Coupling Reactions: The iodine and chlorine atoms serve as excellent handles for Suzuki, Stille, and Negishi cross-coupling reactions to introduce complex aryl and heteroaryl groups.
• Nucleophilic Aromatic Substitution (SNAr): The fluorine and chlorine atoms are activated for displacement by various nucleophiles, enabling rapid diversification of the pyridine scaffold.
• Ligand and Material Science: Acts as a building block for creating specialized ligands for catalysis and as a monomer or precursor for advanced organic electronic materials.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes and tags for studying biological processes due to its ability to be further functionalized.

Basic Information

Product Name	4-Chloro-2-Fluoro-5-Iodopyridine
CAS No.	1184914-20-2
Molecular Formula	C5H2ClFIN
Molecular Weight	273.43 g/mol
Synonyms	5-Iodo-4-chloro-2-fluoropyridine; 2-Fluoro-4-chloro-5-iodopyridine; 4-Chloro-2-fluoro-5-iodopyridine; Pyridine, 4-chloro-2-fluoro-5-iodo-; 1184914-20-2
EINECS	Contact for details

Quality Control

Our 4-Chloro-2-Fluoro-5-Iodopyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment ensures the material meets the high standards required for research and scale-up applications in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.