Description

(2-Chloro-Pyridin-3-Yl)-(3-Hydroxy-Piperidin-1-Yl)-Methanone CAS NO 1184788-76-8 is a high-purity, advanced pharmaceutical intermediate featuring a unique molecular scaffold. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of novel active pharmaceutical ingredients (APIs) with targeted therapeutic effects. Pharmaceutical R&D teams and fine chemical manufacturers need it for developing next-generation treatments, particularly in central nervous system (CNS) and oncology research pipelines.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly those targeting neurological receptors.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• API Synthesis: Employed in the multi-step manufacturing process of potent, small-molecule active pharmaceutical ingredients.
• CNS Drug Development: Integral to creating compounds for potential treatments of disorders like anxiety, depression, and schizophrenia.
• Oncological Agent Precursor: Serves as a building block for kinase inhibitors and other targeted cancer therapies.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting global pharmaceutical development.
• Academic Research: Utilized in university and institutional labs for exploratory pharmacology and chemical biology studies.

Basic Information

Product Name	(2-Chloro-Pyridin-3-Yl)-(3-Hydroxy-Piperidin-1-Yl)-Methanone
CAS No.	1184788-76-8
Molecular Formula	C11H13ClN2O2
Molecular Weight	240.69 g/mol
Synonyms	1-(2-Chloropyridine-3-carbonyl)-3-hydroxypiperidine; 3-Hydroxy-1-[(2-chloro-3-pyridinyl)carbonyl]piperidine; (2-Chloro-3-pyridinyl)(3-hydroxy-1-piperidinyl)methanone; Methanone, (2-chloro-3-pyridinyl)(3-hydroxy-1-piperidinyl)-; 2-Chloro-N-(3-hydroxypiperidin-1-yl)nicotinamide; 1184788-76-8; AKOS025147065
EINECS	Contact for details

Quality Control

Our (2-Chloro-Pyridin-3-Yl)-(3-Hydroxy-Piperidin-1-Yl)-Methanone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the exacting standards required for pharmaceutical R&D. Certificates of Analysis (COA) with full traceability are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.