Description

2-Chloro-3-Fluoro-4-Methoxypyridine is a high-value, multi-functional halogenated pyridine derivative. This compound serves as a critical building block in modern synthetic chemistry, enabling the precise introduction of chlorine and fluorine substituents onto a methoxy-pyridine scaffold. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients, including potential drug candidates and advanced crop protection agents.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules targeting central nervous system (CNS) disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the fluorine atom enhances biological activity and metabolic stability.
• Material Science Research: Serves as a monomer or functionalization agent in the creation of specialty polymers, liquid crystals, and organic electronic materials.
• Chemical Biology & Proteomics: Employed as a versatile scaffold for designing molecular probes, enzyme inhibitors, and labeling reagents in biochemical research.
• Custom Synthesis & Contract Manufacturing: A fundamental starting material for custom synthesis projects and scale-up processes under cGMP or ISO standards.

Basic Information

Product Name	2-Chloro-3-Fluoro-4-Methoxypyridine
CAS No.	1184172-10-8
Molecular Formula	C6H5ClFNO
Molecular Weight	161.56 g/mol
Synonyms	2-Chloro-3-fluoro-4-methoxypyridine; 4-Methoxy-2-chloro-3-fluoropyridine; 3-Fluoro-2-chloro-4-methoxypyridine; 1184172-10-8; Pyridine, 2-chloro-3-fluoro-4-methoxy-; 2-Chloro-3-fluoro-4-pyridinol methyl ether
EINECS	Contact for details

Quality Control

Every batch of 2-Chloro-3-Fluoro-4-Methoxypyridine is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the precise requirements for advanced synthetic applications. Our standard quality commitment includes HPLC purity ≥98% (with higher grades available), identity confirmation by FT-IR and NMR, and stringent control of residual solvents and related substances. A detailed Certificate of Analysis (COA) is supplied with each shipment, and custom specifications can be developed to support your regulatory filings (e.g., FDA, EMA).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to minimize exposure to moisture. Due to its chemical nature, store away from strong bases and fluorides.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.