Description

tert-Butyl 3-Amino-4-Fluorobenzoate is a high-purity fluorinated benzoate derivative serving as a critical building block in advanced organic synthesis. This compound is valued for its tert-butyl ester group and strategically placed amino and fluorine substituents, which are essential for modulating the physicochemical properties of target molecules. It is primarily utilized by research and development chemists and process scale-up teams in the pharmaceutical and agrochemical industries for creating novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and other small molecule drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, where the fluorine atom enhances biological activity and metabolic stability.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for synthesizing fluorinated aromatic components used in electronic display technologies.
• Polymer Modification: Employed to introduce functional aromatic amines into polymer backbones, altering material properties for specialty coatings and engineering plastics.
• Cross-Coupling Reactions: The aromatic amine and halogen (fluorine) provide handles for Suzuki, Buchwald-Hartwig, and other palladium-catalyzed cross-coupling reactions.
• Protecting Group Strategy: The tert-butyl ester acts as a robust protecting group for carboxylic acids during multi-step synthetic sequences, which can be cleaved under acidic conditions.

Basic Information

Product Name	tert-Butyl 3-Amino-4-Fluorobenzoate
CAS No.	1183911-09-2
Molecular Formula	C11H14FNO2
Molecular Weight	211.23 g/mol
Synonyms	3-Amino-4-fluorobenzoic acid tert-butyl ester; 4-Fluoro-3-aminobenzoic acid tert-butyl ester; tert-Butyl 4-fluoro-3-aminobenzoate; Benzoic acid, 3-amino-4-fluoro-, 1,1-dimethylethyl ester; 1,1-Dimethylethyl 3-amino-4-fluorobenzoate; 3-Amino-4-fluorobenzoic acid 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for research and commercial use. We employ advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry to verify identity, purity, and consistency. Certificates of Analysis (COA) are available upon request, detailing batch-specific results for all critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (typically 15-25°C). The compound may be light-sensitive and should be handled under an inert atmosphere for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.