Description

Glucosamine L-5-Methyltetrahydrofolate CAS NO 1181972-37-1 is a specialized, high-purity conjugate molecule designed for advanced nutritional and pharmaceutical applications. This compound combines the structural benefits of glucosamine with the bioactive, metabolically active form of folate, L-5-MTHF, offering superior stability and bioavailability. It is essential for manufacturers in the nutraceutical, pharmaceutical, and clinical nutrition sectors seeking to develop next-generation supplements and therapeutic formulations. This product addresses the critical need for reliable, high-quality ingredients that support methylation processes, joint health, and overall metabolic function.

Application

• Premium Nutraceutical Formulations: As a key active ingredient in high-end dietary supplements targeting joint support, cardiovascular health, and methylation cycle support.
• Pharmaceutical Intermediates: Used in the synthesis of specialized prescription drugs and medical foods designed for patients with folate metabolism disorders (e.g., MTHFR polymorphism).
• Clinical Nutrition Products: Incorporated into medical nutritionals, parenteral feeds, and therapeutic supplements for hospitals and clinical settings.
• Functional Food & Beverage Fortification: For the enrichment of health-focused foods and drinks where a stable, bioavailable form of folate is required.
• Cosmeceutical Applications: Potential use in advanced skincare products for its role in cellular regeneration and repair processes.
• Research & Development: Serves as a critical reference standard and raw material in biochemical, pharmacological, and nutritional science research.

Basic Information

Product Name	Glucosamine L-5-Methyltetrahydrofolate
CAS No.	1181972-37-1
Molecular Formula	C26H42N6O11
Molecular Weight	614.65 g/mol
Synonyms	L-5-MTHF Glucosamine Salt; (6S)-5-Methyltetrahydrofolic acid glucosamine salt; Glucosamine (6S)-5-Methyltetrahydrofolate; Metafolin® Glucosamine Salt (associated with specific grades); Levomefolic acid glucosamine salt; (6S)-5-MTHF glucosamine; Active Folate Glucosamine Complex; Glucosamine Salt of L-Methylfolate
EINECS	Contact for details

Quality Control

Our Glucosamine L-5-Methyltetrahydrofolate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and assay, chiral purity verification, and residual solvent analysis, to ensure it meets stringent specifications for pharmaceutical and nutraceutical use. Certificates of Analysis (COA) are provided with every shipment, and we can support compliance with relevant standards such as cGMP, USP, and FCC upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and potency. For long-term storage, consider desiccated or nitrogen-purged environments.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (6S-isomer)
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 10 ppm
Total Aerobic Microbial Count	≤ 1000 cfu/g
Total Combined Yeasts/Molds	≤ 100 cfu/g

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.