Description

Methyl 3-Oxo-3-[3-(Trifluoromethoxy)Phenyl]Propionate is a high-value fluorinated organic intermediate, specifically a β-keto ester derivative, known for its unique trifluoromethoxy phenyl moiety. This compound is critical for introducing the metabolically stable trifluoromethoxy group into target molecules, enhancing their lipophilicity and biological activity. It is primarily sought after by pharmaceutical and agrochemical R&D teams for the synthesis of advanced active ingredients, including potential drug candidates and novel crop protection agents.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and anti-inflammatory drug discovery.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides where the trifluoromethoxy group improves efficacy and environmental stability.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for synthesizing fluorinated aromatic compounds used in electronic displays and organic light-emitting diodes.
• Advanced Polymer Modification: Employed to introduce fluorine-containing side chains into polymers, enhancing material properties like chemical resistance and thermal stability.
• Custom Synthesis & Contract Manufacturing: A vital reagent for fine chemical and custom synthesis houses serving the life sciences industry.
• Research & Development: Essential for academic and industrial research exploring new fluorinated compounds and their properties.

Basic Information

Product Name	Methyl 3-Oxo-3-[3-(Trifluoromethoxy)Phenyl]Propionate
CAS No.	1181574-09-3
Molecular Formula	C11H9F3O4
Molecular Weight	262.18 g/mol
Synonyms	Methyl 3-oxo-3-[3-(trifluoromethoxy)phenyl]propanoate; 3-Oxo-3-(3-trifluoromethoxyphenyl)propionic acid methyl ester; Methyl 3-(3-(trifluoromethoxy)phenyl)-3-oxopropanoate; 3-(Trifluoromethoxy)benzoylacetic acid methyl ester; Methyl β-keto-3-(trifluoromethoxy)hydrocinnamate; Methyl (3-(trifluoromethoxy)benzoyl)acetate; Propanoic acid, 3-oxo-3-[3-(trifluoromethoxy)phenyl]-, methyl ester
EINECS	Contact for details

Quality Control

Our production of Methyl 3-Oxo-3-[3-(Trifluoromethoxy)Phenyl]Propionate adheres to stringent in-process controls and final batch analysis to ensure consistent high purity and chemical identity. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, impurity profiles, and physical characteristics. Our quality system is designed to meet the exacting standards of GMP and ISO guidelines for fine chemical intermediates, ensuring reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong bases and fluorides. The container should be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.