Description

2-Chloro-1-(1H-Pyrrolo[2,3-B]Pyridin-3-Yl)Ethanone Hydrochloride is a high-purity, advanced pharmaceutical intermediate crucial for modern drug discovery and development. This compound serves as a key synthetic building block for the creation of novel, biologically active molecules targeting a range of therapeutic areas. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the synthesis of kinase inhibitors and other small-molecule therapeutics. Our supply is characterized by stringent quality control, ensuring consistency and reliability for critical R&D and scale-up processes.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of targeted kinase inhibitors and other bioactive heterocyclic compounds.
• Drug Discovery Research: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization campaigns.
• Chemical Biology Probes: Serves as a scaffold for developing tool compounds to study specific enzyme functions and cellular pathways.
• Process Chemistry Development: Employed in route scouting and optimization for the commercial-scale manufacturing of active pharmaceutical ingredients (APIs).
• Academic Research: Utilized in university and institutional labs for the exploration of new synthetic methodologies and novel heterocyclic chemistry.

Basic Information

Product Name	2-Chloro-1-(1H-Pyrrolo[2,3-B]Pyridin-3-Yl)Ethanone Hydrochloride
CAS No.	1181457-88-4
Molecular Formula	C9H8Cl2N2O
Molecular Weight	231.08 g/mol
Synonyms	3-Acetyl-7-azaindole hydrochloride; 1-(1H-Pyrrolo[2,3-b]pyridin-3-yl)-2-chloroethanone hydrochloride; 2-Chloro-1-(7-azaindol-3-yl)ethanone hydrochloride; 3-(2-Chloroacetyl)-1H-pyrrolo[2,3-b]pyridine hydrochloride; 7-Aza-3-acetylindole hydrochloride; 1H-Pyrrolo[2,3-b]pyridine, 1-(2-chloroacetyl)-, hydrochloride; 3-Acetyl-1H-pyrrolo[2,3-b]pyridine hydrochloride
EINECS	Contact for details

Quality Control

Every batch of 2-Chloro-1-(1H-Pyrrolo[2,3-B]Pyridin-3-Yl)Ethanone Hydrochloride is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to support its use in regulated environments, including full characterization by NMR, HPLC, and MS. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each shipment, ensuring traceability and compliance with your internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider the use of desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.