Description

3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzoyl Chloride is a high-value organoboron reagent and a key benzoyl chloride derivative designed for advanced synthetic chemistry. This compound matters because it serves as a versatile bifunctional building block, enabling the simultaneous introduction of a protected boronic acid ester and a highly reactive acid chloride group into target molecules. Pharmaceutical, agrochemical, and advanced materials researchers need it for constructing complex molecular architectures, particularly in cross-coupling reactions and polymer synthesis.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for kinase inhibitors and other small-molecule drugs utilizing Suzuki-Miyaura cross-coupling.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides that require the incorporation of aryl-boronate and benzoyl functionalities.
• Polymer & Material Science: Serves as a monomer or cross-linking agent for creating specialty polymers, liquid crystals, and organic electronic materials with tailored properties.
• Chemical Biology & Bioconjugation: Employed in the design of probes, tags, and linkers for protein modification and bioconjugation strategies due to its dual-reactive sites.
• Organic Synthesis Building Block: Facilitates sequential functionalization in multi-step synthesis, allowing for the precise construction of complex, polyfunctional aromatic compounds.

Basic Information

Product Name	3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzoyl Chloride
CAS No.	1181329-14-5
Molecular Formula	C15H20BClO3
Molecular Weight	294.58 g/mol
Synonyms	3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzoyl chloride; 3-(Pinacolatoboryl)benzoyl chloride; 3-Boronobenzoyl chloride pinacol ester; m-(Pinacolatoboryl)benzoyl chloride; 3-Carboxybenzene boronic acid pinacol ester chloride; 3-(4,4,5,5-Tetramethyl-2-borolan-2-yl)benzoyl chloride; 3-(Pinacolboronato)benzoyl chloride; 3-(Pinacolboryl)benzoyl chloride
EINECS	Contact for details

Quality Control

Our production of 3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzoyl Chloride adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for demanding research and scale-up applications. Each lot undergoes comprehensive analysis, including HPLC for assay and impurity profiling, NMR for structural confirmation, and Karl Fischer titration for moisture content. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at temperatures between 2°C and 8°C (refrigerated) to maximize stability. Due to its hygroscopic and moisture-sensitive nature, the container must be kept sealed under an inert atmosphere (argon or nitrogen) when not in use. Keep away from heat, open flames, and incompatible materials such as strong bases, alcohols, and water.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.