Description

2,8-Diazaspiro[5.5]Undecan-1-One, Hydrochloride (1:1) is a high-purity, advanced pharmaceutical intermediate with the CAS number 1181265-43-9. This compound is a key building block in modern medicinal chemistry, valued for its rigid spirocyclic structure which is instrumental in designing novel drug candidates. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of new therapeutic agents, particularly within central nervous system (CNS) and metabolic disorder research.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs) targeting various disease pathways.
• Medicinal Chemistry Research: Serves as a versatile scaffold for constructing compound libraries in high-throughput screening and structure-activity relationship (SAR) studies.
• Protease Inhibitor Development: The diazaspiro structure is relevant in the design of inhibitors for enzymes like DPP-4, relevant for diabetes treatments.
• CNS Drug Discovery: Used in research programs focused on neurological targets due to its potential to enhance blood-brain barrier penetration and receptor binding.
• Chemical Biology Probes: Employed in the development of tool compounds for studying biological processes and target validation.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the cGMP production of clinical trial materials and commercial APIs.

Basic Information

Product Name	2,8-Diazaspiro[5.5]Undecan-1-One, Hydrochloride (1:1)
CAS No.	1181265-43-9
Molecular Formula	C9H17ClN2O
Molecular Weight	204.70 g/mol
Synonyms	1-Oxo-2,8-diazaspiro[5.5]undecane hydrochloride; 2,8-Diazaspiro[5.5]undecan-1-one HCl; 2,8-Diazaspiro[5.5]undecane-1-one hydrochloride; 1-Oxo-2,8-diazaspiro[5.5]undecane HCl; 1181265-43-9; Spiro[5.5]undecane-1-one, 2,8-diazahydrochloride; 2,8-Diazaspiro[5.5]undecan-1-one monohydrochloride
EINECS	Contact for details

Quality Control

Our 2,8-Diazaspiro[5.5]Undecan-1-One, Hydrochloride (1:1) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and other critical parameters is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.