Description

Ethyl 2-(2-Bromophenyl)-2,2-Difluoroacetate is a high-value, multi-functional fluorinated building block essential for advanced organic synthesis. This compound matters because its unique structure, featuring a difluoroacetate ester and an ortho-bromophenyl group, enables precise molecular construction in complex chemical environments. Pharmaceutical, agrochemical, and advanced material researchers need it as a critical intermediate for developing novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of complex drug candidates, particularly those requiring difluoromethyl or aryl-fluorine motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, where the difluoroacetate moiety can impart unique biological activity.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the synthesis of fluorinated polymers and advanced organic electronic materials, where fluorine atoms can modify electronic properties and stability.
• Chemical Biology Probes: Utilized to build fluorinated analogs of natural products or biomarkers for studying biological pathways and mechanisms.

Basic Information

Product Name	Ethyl 2-(2-Bromophenyl)-2,2-Difluoroacetate
CAS No.	1180536-37-1
Molecular Formula	C10H9BrF2O2
Molecular Weight	279.08 g/mol
Synonyms	Ethyl 2-Bromo-α,α-difluorobenzeneacetate; 2-Bromo-α,α-difluorobenzeneacetic Acid Ethyl Ester; Ethyl (2-Bromophenyl)difluoroacetate; 2-(2-Bromophenyl)-2,2-difluoroacetic Acid Ethyl Ester; (2-Bromophenyl)difluoroacetic Acid Ethyl Ester; Ethyl 2,2-Difluoro-2-(2-bromophenyl)acetate; Difluoro(2-bromophenyl)acetic Acid Ethyl Ester
EINECS	Contact for details

Quality Control

Our Ethyl 2-(2-Bromophenyl)-2,2-Difluoroacetate is produced under strict quality management systems to ensure batch-to-batch consistency and high purity for research and scale-up applications. We provide comprehensive analytical data, including HPLC/GC purity, NMR, and MS confirmation. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is supplied with every batch to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.