Description

3-(Trifluoromethyl)Picolinimidamide Hydrochloride is a high-purity, advanced pharmaceutical intermediate characterized by its unique trifluoromethyl-substituted picolinimidamide structure. This compound is critical for medicinal chemistry research and development, offering a versatile building block for the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate fluorine-containing motifs into target molecules.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potential drug candidates, particularly those targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to introduce the metabolically stable and lipophilic trifluoromethyl group.
• Agrochemical Synthesis: Serves as a precursor for developing new generation herbicides, fungicides, and insecticides with enhanced efficacy and environmental profile.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Utilized to create molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and commercial production projects.

Basic Information

Product Name	3-(Trifluoromethyl)Picolinimidamide Hydrochloride
CAS No.	1179361-68-2
Molecular Formula	C7H7ClF3N3
Molecular Weight	225.60 g/mol
Synonyms	3-(Trifluoromethyl)picolinimidamide HCl; 2-Pyridinecarboximidamide, 3-(trifluoromethyl)-, hydrochloride (1:1); 3-(Trifluoromethyl)-2-pyridinecarboximidamide hydrochloride; 3-Trifluoromethylpicolinimidamide hydrochloride; 3-(Trifluoromethyl)pyridine-2-carboximidamide hydrochloride; Picolinimidamide, 3-(trifluoromethyl)-, hydrochloride
EINECS	Contact for details

Quality Control

Our 3-(Trifluoromethyl)Picolinimidamide Hydrochloride is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with customer specifications and supporting regulatory filings for research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.